Results 51 to 60 of about 137,819 (261)

Neutron Capture Cross Section Measurement on 91Zr at J-PARC/MLF/ANNRI

EPJ Web of Conferences, 2015
The neutron capture cross section measurement on 91Zr was performed at neutron TOF beam line ANNRI installed at J-PARC/MLF. Prompt capture gamma rays from the sample were detected with an array of large Ge detectors at a distance of 21.5 m from the ...
Hori Jun-ichi, Yashima Hiroshi, Nakamura Shoji, Furutaka Kazuyoshi, Hara Kaoru Y., Harada Hideo, Hirose Kentaro, Igashira Masayuki, Katabuchi Tatsuya, Kimura Atsushi, Kino Koichi, Kitatani Fumito, Kiyanagi Yoshiaki, Koizumi Mitsuo, Mizumoto Motoharu, Sano Tadafumi, Takahashi Yoshiyuki, Toh Yosuke   +17 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Perspectives on Engineering Uncertainty

This open access book considers the role of uncertainty in the design and development of large-scale engineering systems. The focus of the book is the safe behaviour of nuclear power plants in both routine operations and in incident situations. The book introduces various types of uncertainty and addresses the extent to which uncertainties may be ...
Nuttall, William, Patelli, Edoardo, Smith, Ewan, Webbe-Wood, David, Middleburgh, Simon   +4 more
openaire   +4 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Initiation and Development of Supercritical Carbon Dioxide Nuclear Energy and Power System

Yuanzineng kexue jishu, 2023
The supercritical carbon dioxide (S-CO2) nuclear energy and power system uses S-CO2 as the working fluid to convert nuclear heat directly or indirectly into electricity or mechanical energy.
HUANG Yanping;LIU Minyun;ZHUO Wenbin;YE Lü;TANG Jia;CHEN Yaoxing;LIU Ruilong;LIU Xiuting;TANG Yu;ZHAO Xuebin;GONG Houjun;ZAN Yuanfeng
doaj  

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Multiple DNA damages induced by water radiolysis demonstrated using a dynamic Monte Carlo code

Communications Chemistry
Multiple DNA damage resulting from different nearby ionizations of water molecules is an important process of the initial step of radiobiological effects.
Takeshi Kai, Tomohiro Toigawa, Yusuke Matsuya, Yuho Hirata, Hidetsugu Tsuchida, Yuma Ito, Akinari Yokoya   +6 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source