Results 161 to 170 of about 612,140 (269)

The mRNA export factor UAP56 is required for dendrite and synapse pruning via actin regulation in Drosophila. [PDF]

J Cell Sci
Frommeyer SM, Gigengack U, Rode S, Davies M, Wolterhoff N, Rumpf S.   +5 more
europepmc   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Cell and Nuclear Size Is Associated with Chromosomal Instability and Tumorigenicity in Cancer Cells That Undergo Whole Genome Doubling. [PDF]

Cancer Res
Bloomfield M, Huth SM, McCausland DS, Saad R, Bano N, Chau TN, Sweet ML, Baudoin NC, McCaffrey A, Fluet K, Schmelz EM, Ben-David U, Cimini D.   +12 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Enhanced expression of ADAMTS1 in ovarian carcinomas: loss of ADAMTS1 expression instigates cellular reprogramming of extracellular matrix ensuing altered plasticity, augmented migration and attenuated adhesion. [PDF]

J Biomed Sci
Escalona RM, King D, Lokman NA, Oehler MK, Ricciardelli C, Kannourakis G, Ahmed N.   +6 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Dispensable players: N-WASP and WASP are not crucial for homology-directed DNA repair. [PDF]

EMBO Rep
Le Phan TH, Buchard A, Brakebusch C.
europepmc   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Integrin α6-Targeted Positron Emission Tomography Imaging of Colorectal Cancer

ACS Omega, 2019
Yi-Tai Xiao, Chao Zhou, Jia-Cong Ye, Xiao-Chun Yang, Zhi-Jian Li, Xiao-Bin Zheng, Yan Mei, Xin-Ling Li, Wei-Guang Zhang, Wei Fan, Mu-Sheng Zeng, Jian-Jun Li, Guo-Kai Feng   +12 more
doaj   +1 more source

USP7 facilitates brain tumor survival upon glucose deprivation by regulating phosphofructokinase muscle-type nuclear translocation in mice. [PDF]

PLoS Biol
Wu S, Cao R, Huang X, Feng Q, Zhang Y, Gao H, Tao B, Liang J, Yang W.   +8 more
europepmc   +1 more source