Results 181 to 190 of about 4,295,257 (299)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

The oligosaccharyltransferase TaOST1B promotes viral infection by enhancement of RNA silencing suppression in wheat. [PDF]

Nat Commun
Liu J, Wang X, Liu Y, Yang J, Shi C, Yong B, Zhao Y, Jiang Y, Hu H, Feng L, Guo J, Zhang T, Zhong K, Liu P, Tang K, Chen F, Chen J, Yang J.   +17 more
europepmc   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Post-transcriptional regulation of Profilin-2 by microRNAs and RNA-binding proteins forms a critical regulatory node for early embryonic cell fate decisions. [PDF]

PLoS Genet
Sangokoya C, Rosso IR, Ghandehari-Alavijeh R, Blelloch R.   +3 more
europepmc   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Astragaloside IV confers vascular protection after traumatic brain injury through an Nrf2-dependent mechanism involving VWF. [PDF]

IBRO Neurosci Rep
Feng S, Sun B, Li M, Tian L, Sun G.
europepmc   +1 more source

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

SIRT6-Mediated Deacetylation of ATF3 Promotes Silica-Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α. [PDF]

Adv Sci (Weinh)
Cheng D, Bu W, Wang F, Jin Y, Liu R, Zhao R, Wang X, Jiang M, Shen J, Cheng X, Chen Z, Zhu L, Li J, Ge Z, Miao S, Xu H, Zhou X, Wang D, Zhao X.   +18 more
europepmc   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Magnetic character of the low-energy enhancement in ⁷⁰Zn. [PDF]

Nature
Ronning EK, Richard AL, Liddick SN, Spyrou A, Ringle R, Arora H, Berg HC, Berkman JM, Bleuel DL, Bosmpotinis K, Campbell SE, Chen X, Crider BP, Coleman RJ, DeYoung PA, Doetsch AA, Erington H, Gaballah T, Gamage ND, Good EC, Greaves B, Hartley AC, Huffman J, Ireland CM, Izzo C, Jain R, Larsen AC, Larsson JEL, Lubna RS, Maier FM, Mogannam MJ, Mücher D, Mumpower MR, Owens-Fryar G, Ogunbeku TH, Scriven DP, Smith MK, Sumithrarachchi CS, Sweet A, Taft K, Tsantiri A, Uthayakumaar S, Wiedeking M.   +42 more
europepmc   +1 more source