Results 201 to 210 of about 4,295,257 (299)

Region Specific miRNA–mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Adya Sapra, Nagendra K. Rai, Timothy D. Niepokny, Haley Courtney, Ajai Tripathi, Ranjan Dutta   +5 more
wiley   +1 more source

Identification of MNT fragments produced by an energy-degraded 238 U beam on a 209 Bi target at the FRS Ion Catcher. [PDF]

Eur Phys J A Hadron Nucl
Shraier A, Constantin P, Dickel T, Mardor I, Mollaebrahimi A, Amanbayev D, Andrés SAS, Bergmann J, Ge Z, Haettner E, Kar D, Kripko-Koncz G, Kumar D, Mahajan K, Morrissey DJ, Narang M, Plaß WR, Scheidenberger C, Simonov M, Tortorelli N, Yu J, Ahokas J, Amorim B, Bagchi S, Bajzek M, Balabanski DL, Botsiou K, Charviakova V, Eronen T, Glöckner S, Hornung C, Hubbard N, Jaries A, Kalantar-Nayestanaki N, Kankainen A, Karmakar A, Lozeva R, Rodríguez-Sánchez JL, Mitsiou I, Reiter MP, Piasetzky E, Piau V, Podolyák Z, Prajapat R, Prajapati D, Purushothaman S, Reponen M, Rocco E, Ruotsalainen J, Kostyleva D, Singh SK, Spătaru A, State A, Stefănescu I, Tanaka YK, Trache L, Welde L, Zhao J.   +57 more
europepmc   +1 more source

The Comprehensive Live Cell‐Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu, Jie Ding, Yupeng Du, Guibao Luo, Jinming Li, Rui Liu, Xiaoyi Xu, Xiao Li, Minshu Li, Wei Jiang, Chunsheng Yang   +10 more
wiley   +1 more source

Nationwide Survey of Association Between Fever and Epileptic Seizure in CDKL5 Deficiency Disorder Revealed Therapeutic Implications

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective CDKL5 deficiency disorder (CDD) is a rare, severe developmental and epileptic encephalopathy. There is a pressing need to develop effective and sustainable therapeutic strategies. We aimed to investigate the causal association between febrile episodes and epileptic seizures for therapeutic implications in CDD patients.
Siyi Wang, Jialin Du, Jinghui Liu, Dongmei Hu, Hongxin Wang, Xiaoxiao Man, Lehong Gao, Shimin Hu, Xianghong Meng, Hongyang Zhao, Minjing Hu, Yingxue Yang, Zhiqi Xiong, Liankun Ren   +13 more
wiley   +1 more source

Cohesin prevents local mixing of condensed euchromatic domains in living human cells. [PDF]

Nat Genet
Shimazoe MA, Iida S, Minami K, Higashi K, Tamura S, Kobayashi Y, Fujishiro S, Xiong L, Nakazato K, Ashwin SS, Nishiyama T, Nagata Y, Kanemaki MT, Kawaguchi A, Ohkawa Y, Schermelleh L, Toyoda A, Xie L, Kurokawa K, Ochiai H, Sasai M, Maeshima K.   +21 more
europepmc   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Barrier-to-autointegration factor protects against the cGAS-STING response to chromatin bridges. [PDF]

PLoS Genet
Chastant L, Normandin K, El-Mortada F, Servant MJ, Archambault V.   +4 more
europepmc   +1 more source

Mechanochemical Synthesis and Characterization of Nanostructured ErB4 and NdB4 Rare‐Earth Tetraborides

Advanced Engineering Materials, Volume 27, Issue 6, March 2025.
ErB4 and NdB4 nanostructured powders are produced by mechanochemical synthesis. 5 h mechanical alloying and 4 M HCl acid leaching are used in the production. ErB4 and NdB4 powders exhibit maximum magnetization of 0.4726 emu g−1 accompanied with an antiferromagnetic‐to‐paramagnetic phase transition at about TN = 18 K and 0.132 emu g−1 with a maximum at ...
Burçak Boztemur, Faruk Kaya, Bora Derin, Mustafa Lütfi Öveçoğlu, Ju Li, Duygu Ağaoğulları   +5 more
wiley   +1 more source

Dual spectroscopy technique for vapor-phase chlorides and iodine detection in nuclear systems. [PDF]

RSC Adv
Austin R, LeCroy G, Gakhar R, Roper R, Meiers J, Williams A.   +5 more
europepmc   +1 more source

What Do Large Language Models Know About Materials?

Advanced Engineering Materials, EarlyView.
If large language models (LLMs) are to be used inside the material discovery and engineering process, they must be benchmarked for the accurateness of intrinsic material knowledge. The current work introduces 1) a reasoning process through the processing–structure–property–performance chain and 2) a tool for benchmarking knowledge of LLMs concerning ...
Adrian Ehrenhofer, Thomas Wallmersperger, Gianaurelio Cuniberti   +2 more
wiley   +1 more source