Results 201 to 210 of about 9,127,806 (365)

Growth Differentiation Factor 15 Elevation in the Central Nervous System Is Associated With Failure to Thrive in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Alexander disease (AxD) is a severe neurodegenerative disorder caused by gain‐of‐function mutations in the gene for GFAP, which lead to protein aggregation and a primary astrocytopathy. Symptoms vary, but failure to thrive (FTT) and frequent emesis are common and cause significant morbidity. Here we investigate GDF15, a member of the
Tracy L. Hagemann, Michelle M. Sonsalla, Cora Luzinski, Fernando Zacahua, David A. Harris, Dudley W. Lamming, Albee Messing   +6 more
wiley   +1 more source

The Fading Art of Microsphere-Derived Measurement of Absolute Myocardial Blood Flow. [PDF]

Ann Nucl Cardiol
Christian TF.
europepmc   +1 more source

SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas, Pablo Iruzubieta, Alberto Damborenea, Laura Pérez‐Fernández, Inmaculada Azorín, Juan Carlos Jiménez García, Ana Töpf, Pilar Martí, Lorena Fores‐Toribio, María Manterola, Rosana Blanco‐Mañez, Oihane Pikatza‐Menoio, Sonia Alonso‐Martín, Volker Straub, Aitziber L. Cortajarena, Adolfo López de Munain, David De Sancho, Lorea Blázquez, Juan J. Vilchez   +18 more
wiley   +1 more source

Abrupt structural transition in exotic molybdenum isotopes unveils an isospin-symmetric island of inversion. [PDF]

Nat Commun
Ha J, Recchia F, Lenzi SM, Iwasaki H, Dao DD, Nowacki F, Revel A, Aguilera P, de Angelis G, Ash J, Bazin D, Bentley MA, Biswas S, Carollo S, Cortes ML, Elder R, Escudeiro R, Farris P, Gade A, Ginter T, Grinder M, Li J, Napoli DR, Noji S, Pereira J, Pigliapoco S, Pompermaier A, Poves A, Rezynkina K, Sanchez A, Wadsworth R, Weisshaar D.   +31 more
europepmc   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon. [PDF]

Nat Commun
Halley-Stott RP, Hörmanseder E, Jullien J, Pasque V.   +3 more
europepmc   +1 more source

RRP9 Promotes Esophageal Squamous Cell Carcinoma Progression through E2F1 Transcriptional Regulation of CDK1

Advanced Biology, EarlyView.
The study reveals that RRP9 is abnormally highly expressed in ESCC tissues and is closely associated with poor prognosis in patients. Furthermore, it is found that RRP9 promotes ESCC progression through enhancing the E2F1‐mediated transcriptional regulation of CDK1.
Gang He, Yilong Wan, Yanbo Zhu, Bo Peng, Shengxiang Shao, Xinyi Zou, Zhenyu Han, Jiaxi Li, Sheng Ju, Xin Tong, Jun Zhao, Hansi Liang, Liuqing Zhang, Jiashi Xiong, Dong Jiang   +14 more
wiley   +1 more source

Nuclear rupture in confined cell migration triggers nuclear actin polymerization to limit chromatin leakage. [PDF]

EMBO J
Kamaras C, Frank D, Wang H, Drepper F, Huesgen PF, Grosse R.   +5 more
europepmc   +1 more source

Instant release of fission products in leaching experiments with high burn-up nuclear fuels in the framework of the Euratom project FIRST- Nuclides

, 2016
Karel Lemmens, E. González-Robles, Bernhard Kienzler, Enzo Curti, Daniel Serrano‐Purroy, Rosa Sureda, Albert Martínez-Torrents, Olivia Roth, E. Slonszki, Thierry Mennecart, Ines Günther-Leopold, Zoltán Hózer   +11 more
openalex   +2 more sources

Lung Microphysiological System Validates Novel Cell Therapy for Acute Respiratory Distress Syndrome

Advanced Biology, EarlyView.
This study aims to evaluate the efficacy of primed mesenchymal stem cells (pMSCs) as an alternative treatment for Acute Respiratory Distress Syndrome (ARDS), based on a novel lung microphysiological system (MPS) to test the efficacy of pMSCs over the standard treatment, Dexamethasone.
Bokyong Kim, So‐Hui Kim, Jieun Kim, Eun‐Young Eo, Hyung‐Jun Kim, Jae Ho Lee, Choon‐Taek Lee, Taeho Kong, Su Kyoung Seo, Seunghee Lee, Jeongbin Park, Young‐Jae Cho   +11 more
wiley   +1 more source