Results 41 to 50 of about 2,405,307 (307)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Application of wavelet transform in anti-Compton phoswich detector for gamma spectrum

Nuclear Engineering and Technology
The response of an anti-Compton phoswich detector to gamma rays was investigated using Monte-Carlo method, and the pulses from different crystal cases, including gamma deposition only in the LaBr3(Ce) or CsI(Tl) crystal and coincidence in both crystals ...
Changqi Liu, Kai Tao, Jinqiu Peng, Liming Huang, Dejun E, Weimin Li, Xiaohou Bai, Zhanwen Ma   +7 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Radioactive gas diffusion simulation and inhaled effective dose evaluation during nuclear decommissioning [PDF]

, 2021
During the decommissioning of the nuclear facilities, the radioactive gases in pressure vessels may leak due to the demolition operations. The decommissioning site has large space, slow air circulation, and many large nuclear facilities, which increase ...
Liu, Y-K, Yang, L-Q, Chen, Z-T, Ayodeji, A, Long, Z-Y, Peng, M-J   +5 more
core   +1 more source

The Oxford submicron nuclear microscopy facility

Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 1991
Abstract This paper describes the unique nuclear microprobe facility now established in the University of Oxford. The system, which uses a dedicated small accelerator, operates on a regular daily basis, therefore the emphasis of the design has been on achieving reliable, high-quality performance while minimising overheads of alignment in the focusing
Grime, G, Dawson, M, Marsh, M, Mcarthur, I, Watt, F   +4 more
openaire   +2 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Nonlinear Dynamics of Cylindrical Waves in Isentropic Plasma

Physics
Based on the hydrodynamic description, the dynamics of nonlinear cylindrical waves in an isentropic plasma are investigated. The problem is considered in an electrostatic formulation for a two-dimensional plasma medium where ions form a stationary ...
Alexander R. Karimov, Grigoriy O. Buyanov   +1 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

THE MENTAL IMAGE OF NUCLEAR AND RADIOLOGICAL FACILITIES AND THEIR RELATIONSHIP TO SOCIETAL ACCEPTANCE AND THE SOCIAL PROBLEMS RESULTING FROM THEM [PDF]

Journal of Environmental Science
This study aims to clarify the correlational relationships between social problems and the mental image of nuclear and radiological facilities. The problem of the study is to discover and measure the mental image of nuclear and radiological facilities ...
Ahmed Abdel Ghani, Hatem Ahmed, Ahmed Shoman, Mohamed Mohamed   +3 more
doaj   +1 more source