Results 121 to 130 of about 3,380,324 (296)

PWR Transition to a Higher Power Core Using Annular Fuel

, 2007
The internally and externally cooled annular fuel is a new type of fuel for PWRs that enables an increase in core power density by 50% within the same or better safety margins as traditional solid fuel.
Kazimi, Mujid S., Hejzlar, Pavel, Beccherle, J.   +2 more
core  

METTL7A Downregulation Drives SLC1A5‐Mediated Glutamine Competition to Promote Tumor Proliferation and Suppress CD8+ T Cell Immunity in Gastric Cancer

Advanced Science, EarlyView.
GC cells enhance glutamine accumulation by upregulating SLC1A5 expression. This upregulation not only boosts GC cell proliferation, but also outcompetes CD8+ T cells for glutamine and suppresses their antitumor immunity. Mechanistically, METTL7A deficiency in GC induces SLC1A5 overexpression via an m6A‐dependent pathway and N‐glycosylation ...
Mingjun Sun, Shuwei Dang, Dazhi Zhou, Lixian Ding, Xun Sun, Wei Suo, Jirui Niu, Qingzhu Yang, Zhicheng Zhang, Yanyan Sun, Jinxing Li, Zhongsheng Chen, Tao Ban, Yingji Wang, Tianzhu Li, Ming Liu, Guodong Li   +16 more
wiley   +1 more source

Assessment of helical-cruciform fuel rods for high power density

, 2010
In order to significantly increase the power density of Light Water Reactors (LWRs), the helical-cruciform (HC) fuel rod assembly has been proposed as an alternative to traditional fuel geometry.
McKrell, Thomas J., Kazimi, Mujid S., Conboy, Thomas M.   +2 more
core  

Developments in reprocessing of spent nuclear fuels for the thorium fuel cycle

, 2015
Thorium, which is a fissile nuclide, was considered as a fuel for nuclear power plants in the beginning of the nuclear era. Then it was more or less forgotten for 30-40 years but is now gaining renewed, increased interest.
Christian Ekberg, Ekberg, Christian, Ekberg, Christian,   +2 more
core   +1 more source

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

Innovative Fuel Designs for High Power Density Pressurized Water Reactor

, 2005
One of the ways to lower the cost of nuclear energy is to increase the power density of the reactor core. Features of fuel design that enhance the potential for high power density are derived based on characteristics of the pressurized water reactor ...
Kazimi, Mujid S., Hejzlar, Pavel, Feng, D.   +2 more
core  

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Feasibility of Breeding in Hard Spectrum Boiling Water Reactors with Oxide and Nitride Fuels

, 2011
This study assesses the neutronic, thermal-hydraulic, and fuel performance aspects of using nitride fuel in place of oxides in Pu-based high conversion light water reactor designs.
Kazimi, Mujid S., Feng, Bo, Forget, Benoit   +2 more
core  

Scalable Multilayer PTFE‐Reinforced Membranes for Durable, High‐Current‐Density Hydroxide Exchange Membrane Water Electrolysis in Dilute Alkali

Advanced Science, EarlyView.
Low‐Tg HEMs are designed to improve membrane‐electrode adhesion by promoting intimate contact with catalyst layers. After hydration, the membrane develops a hydrogel‐like network that supports water uptake and ion transport while retaining mechanical robustness.
Zhiwei Ren, Yun Zhao, Rui Zhang, Tao Wei, Yingran Zhu, Yangkai Han, Tongzhou Li, Haitao Zhang, Zhigang Shao   +8 more
wiley   +1 more source

A PWR Self- Contained Actinide Transmutation System

, 2006
Elements of the new Global Nuclear Energy Partnership (GNEP) initiative in the US call for the expansion of domestic use of nuclear power and the minimization of nuclear waste.
Shatilla, Y., Kazimi, Mujid S., Hejzlar, Pavel   +2 more
core