Results 101 to 110 of about 355,529 (299)

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Nuclear safety issues for fusion power plants

, 2019
Developing a robust safety case is a key step in the development of a fusion power reactor for electricity generation. Plans for fusion power reactors are already underway and before nuclear facilities are licensed, they must demonstrate they satisfy ...
Williams, Laurence, Lukacs, Matthew
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Clearing the seven obstacles on the road to fusion power [PDF]

, 2010
Change of title : Nuclear fission and fusion fast breeder technology, generation IV reactors, supply chain issues, ITER materials research.
Lopes Cardozo, N.J., Lopes Cardozo, NJ Niek   +1 more
core  

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Evidence of⁹Be  +  pnuclear reactions during 2ω_CHand hydrogen minority ICRH in JET-ILW hydrogen and deuterium plasmas

, 2018
International audienceThe intensity of 9Be p nuclear fusion reactions was experimentally studied during second harmonic (2omega CH) ion-cyclotron resonance heating (ICRH) and further analyzed during fundamental hydrogen minority ICRH of JET-ILW hydrogen ...
V. Goloborodko, Krasilnikov, A. V., Afanasyev, V. I., Popovichev, S. V., C. Giroud, Mironov, M. I., Giroud, C., van Eester, D., Kiptily, V., V. Kiptily, V.I. Afanasyev, M.I. Mironov, null null, Goloborodko, V., D. Van Eester, C. Hellesen, S.V. Popovichev, Hellesen, C., E. Lerche, A.V. Krasilnikov, Lerche, E., Contributors, Jet, Hellesen, Carl,   +22 more
core   +1 more source

Speciation and radiation stability of Cr and Ln “Grey-Phases” within Cr-doped (Ln,U)O2 spent fuel model materials

npj Materials Degradation
Cr-doped UO₂ fuels are increasingly adopted for their superior in-reactor performance compared to undoped UO₂, but their spent fuel behaviour, particularly potential Cr speciation and fission product reactivity, remains poorly understood.
Daniil Shirokiy, Andrey Bukaemskiy, Maximilian Henkes, Elena F. Bazarkina, Christoph Hennig, Andrew Ryan, Martina Klinkenberg, Murat Güngör, Mara McCleary, Julien Marquardt, Andrew Fitch, Kristina O. Kvashnina, Dirk Bosbach, Gabriel L. Murphy   +13 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

You complete me: tumor cell-myeloid cell nuclear fusion as a facilitator of organ-specific metastasis. [PDF]

Front Oncol, 2023
Cozzo AJ, Coleman MF, Hursting SD.
europepmc   +1 more source