Results 81 to 90 of about 384,818 (233)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
On the Cosmic Nuclear Cycle and the Similarity of Nuclei and Stars
, 2005 Repulsive interactions between neutrons in compact stellar cores cause luminosity and a steady outflow of hydrogen from stellar surfaces. Neutron repulsion in more massive compact objects made by gravitational collapse produces violent, energetic ...
Manuel, O. +2 more
core +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Scientific ReportsThis study investigates the surface modification of Fluorinated Polytetrafluoroethylene PTFE and Non-Fluorinated polyethylene PE, two widely used polymers with inherent hydrophobicity and poor adhesion, using atmospheric air plasma generated by Surface ...
Soolmaz Jamali, Ameneh Kargarian
doaj +1 more source
Effects of mass renormalization on the surface properties of heavy-ion fusion potential
, 1995 We discuss the effects of fast nuclear excitations on heavy-ion fusion reactions at energies near and below the Coulomb barrier. Using the fusion of two $^{40}$Ca nuclei as an example and the inversion method, we show that the mass renormalization ...
Hagino, K., Takigawa, N.
core
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Fusion and breakup in the reactions of 6,7Li and 9Be
, 2004 We develop a three body classical trajectory Monte Carlo (CTMC) method to dicsuss the effect of the breakup process on heavy-ion fusion reactions induced by weakly bound nuclei.
Dasgupta, M., Hagino, K., Hinde, D. J.
core +2 more sources
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
, 2011 Molecular dynamics in 2-D accompanied by granular model provides an opportunity to investigate binding between nuclei particles and its properties that arises during collision in a fusion reaction.
Kurniadi, Rizal +3 more
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source