Results 81 to 90 of about 355,529 (299)

Cross-code comparison of the edge codes SOLPS-ITER, SOLEDGE2D and UEDGE in modelling a low-power scenario in the DTT

, 2021
Submitted for publication in Nuclear FusionAs reactor-level nuclear fusion experiments are approaching, a solution to the power exhaust issue in future fusion reactors is still missing.
De Marchi, E., LaBombard, Brian, Moscheni, M., Wu, H., Carati, C., Innocente, P., Zanino, R., Subba, F., Wigram, Mike, Greenwald, M., Meineri, C.   +10 more
core   +1 more source

Stability analysis of plasma waves driven by runaway electrons in tokamak hot plasmas

Nuclear Fusion
The local stability analysis of plasma waves driven by runaway electrons (REs) has been performed considering hot plasma Maxwellian background, with electron and ion temperatures of the order of 1 keV.
C. Castaldo, L. Della Volpe, R. Fedele, W. Bin, P. Buratti, A. Cardinali, F. Napoli, M. Marinucci, G. Apruzzese, C. Cianfarani, E. Giovannozzi, O. Tudisco   +11 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Plasma radiation studies in Magnum-PSI using resistive bolometry [PDF]

, 2018
Both the physics of divertor detachment and vapour shielding are characterized by a relatively large amount of radiation produced in the divertor. The linear plasma generator Magnum-PSI is well-suited to study such processes due to its ITER-divertor ...
Reinke, M. L., Morgan, T. W., Lavrijsen, R.; id_orcid, Van De Sanden, M. C.M., van Eden, G.G., van de Sanden, MCM, Morgan, TW, van Eden, G. G., Perillo, R, Morgan, TW Thomas, Perillo, R., Krijger, B JM, Perillo, R Renato, Van Der Bijl, G., Lavrijsen, R, Krijger, B., van der Bijl, G, Krijger, B, van Eden, GG, Brons, S, Huber, S. P., Sanden, MCM Richard van de, Eden, GG Stein van, Krijger, B. J. M., Bijl, G Van Der, M. C. M. van de Sanden, Reinke, ML, Huber, SP, Reinke, M L, Brons, S., Lavrijsen, R Reinoud, Lavrijsen, R., Huber, S P   +32 more
core   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Physics-based machine learning toolbox for probing concentration under diffusive regime in microfluidics devices

Communications Physics
Microfluidics experiments offer high-resolution insights into transport and chemical processes in porous media, yet direct measurement of evolving concentration profiles remains challenging. Numerical simulations can serve as virtual probes but are labor-
Ryan Santoso, Yuankai Yang, Mara Lönartz, Jenna Poonoosamy   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Radiative type-III ELMy H-mode in all-tungsten ASDEX Upgrade [PDF]

, 2012
The type-III ELMy H-mode might be the solution for an integrated ITER operation scenario fulfilling the fusion power amplification factor (output fusion power to input heating power) of Q = 10 with simultaneous acceptable steady-state and transient power
Rooij, van, G.J.; id_orcid, Herrmann, A., G. J. van Rooij, Potzel, S., Fischer, R., Rooij, van, G.J., van Rooij, G.J., Team, ASDEXUpgrade, Neu, R., Eich, T., Rooij, G. V. van, Zielinski, J.J., Zielinski, J. J., ASDEX Upgrade Team, Rooij, G., Zielinski, J., Rapp, J., Kallenbach, A.   +17 more
core   +1 more source

DIII-D research advancing the physics basis for optimizing the tokamak approach to fusion energy

, 2023
DIII-D physics research addresses critical challenges for the operation of ITER and the next generation of fusion energy devices. This is done through a focus on innovations to provide solutions for high performance long pulse operation, coupled with ...
White, Anne
core   +1 more source