Results 61 to 70 of about 2,595,567 (290)

Evidence of a thermo-diffusion pinch on particle transport in FTU discharges close to density limit

Nuclear Materials and Energy, 2017
In FTU, the density profile in the presence of large MARFE becomes more and more peaked with increasing density, forming strong density gradients close to the radial region affected by the MARFE.
O. Tudisco, C. Meineri, G. Apruzzese, O. D’Arcangelo, E. Giovannozzi, M. Marinucci, C. Mazzotta, G. Pucella   +7 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

SIMMER-III/ANSYS coupling (Preliminary development and validation activities of an integral tool for the design and analysis of WCLL components)

Mechanical Engineering Journal, 2023
In the framework of the development of fusion energy, one of the most prominent technologies arising to address the issues of tritium breeding and power conversion is the Water-Cooled Lithium-Lead (WCLL).
Nicolò BADODI, Marica EBOLI, Antonio CAMMI, Alessandro DEL NEVO   +3 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Integrated core–SOL–divertor modelling for ITER including impurity: effect of tungsten on fusion performance in H-mode and hybrid scenario [PDF]

, 2015
The compatibility of two operational constraints—operation above the L–H power threshold and at low power to divertor—is examined for ITER long pulse H-mode and hybrid scenarios in integrated core–scrape off layer (SOL)–divertor modelling including ...
Polevoi, A. R., da Silva Aresta Belo, P., Telesca, G., J. Garcia, Litaudon, X., Zagorski, R., Fable, E., X. Litaudon, Belo, P., Garcia, J., Kochl, F., Hobirk, J., Joffrin, E., Hogeweij, G., Ivanova-Stanik, I., Hogeweij, G. M. D., Köchl, Florian, Hogeweij, G.M.D., Garzotti, L., Polevoi, A., Polevoi, A.R., Voitsekhovitch, I., JET Contributors   +22 more
core   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source