Results 51 to 60 of about 2,595,567 (290)

Design of a Prototypical Mock-Up for the Experimental Investigation of WCLL First-Wall Performances

Energies, 2023
A large research effort is currently ongoing within the framework of the EUROfusion consortium for the study and design of a water-cooled lithium–lead (WCLL) breeding blanket (BB).
Pietro Maccari, Pietro Arena, Ranieri Marinari, Amelia Tincani, Alessandro Del Nevo   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Combined high fluence and high cycle number transient loading of ITER-like monoblocks in Magnum-PSI [PDF]

, 2021
Combined high fluence and high cycle number transient loading of ITER-like monoblocks in Magnum-PSI T.W. Morgan, Y. Lia,M. Baldenb, S. Brezinsekc, G. De TemmermandDIFFER -Dutch Institute for Fundamental Energy Research, De Zaale 20, 5612 AJ Eindhoven ...
Morgan, T. W., De Temmerman, G., Morgan, T., T.W. Morgan, Li, Yun, M. Balden, S. Brezinsek, Li, Y., Brezinsek, S., Balden, M., Y. Li, G. De Temmerman, Morgan, T.W., Balden, M. ; https://orcid.org/   +13 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Plasma detachment study of high density helium plasmas in the Pilot-PSI device [PDF]

, 2016
We have investigated plasma detachment phenomena of high-density helium plasmas in the linear plasma device Pilot-PSI, which can realize a relevant ITER SOL/Divertor plasma condition.
Morgan, T. W., van der Meiden, H.J., OHNO, Noriyasu, Vernimmen, J. W. M., Meiden, H.J. van der, Hayashi, Y., Morgan, TW Thomas, Kajita, S, Masuzaki, S., Ješko, K., Yoshikawa, M., Van Der Meiden, HJ HJ, Vernimmen, J.W.M., Ohno, N., Ohno, N, Kajita, S., van der Meiden, H. J., Masuzaki, S, Hayashi, Y, Yoshikawa, M, Vernimmen, JWM, Morgan, T.W., Jesko, K Karol, MASUZAKI, Suguru, Hayashi, Yuki   +24 more
core   +1 more source

Predictive multi-channel flux-driven modelling to optimise ICRH tungsten control and fusion performance in JET [PDF]

, 2020
The evolution of the JET high performance hybrid scenario, including central accumulation of the tungsten (W) impurity, is reproduced with predictive multi-channel integrated modelling over multiple confinement times using first-principle based core ...
Ficker, O., Graves, J. P., Koechl, F.,, Valisa, M.,, Graves, J. P.,, Casson, F. J., Mylnar, J.,, Garzotti, L.,, Challis, C. D.,, Jonsson, Thomas,, Bilato, R.,, JET Contributors, Kirov, K.,, Graves, J.P., Casson, F., Knight, P.J., Knight, P.,, Jet, Contributors, Angioni, C.,, Knight, P., Corrigan, G., Sertoli, M.,, Mylnar, J., Patten, H., Johnson, T., Baranov, Y., Challis, C., Angioni, C., Czarnecka, A.,, Angioni, C. ; https://orcid.org/, Garzotti, L., Challis, C.D., Kirov, K., Lerche, E., Challis, C. D., Casson, F. J.,, Czarnecka, A., Frassinetti, L., Patten, H.,, Koechl, F., Graves, J., Bourdelle, C., Casson, F.J., Mantsinen, M.,, Goniche, M., Contributors, JET, Belli, E., Lerche, E.,, Belli, E. A., Breton, S.,, Citrin, J., Frassinetti, Lorenzo,, Citrin, J.,, Corrigan, G.,, Sertoli, M., Breton, S., Knight, P. J., Belli, E. A.,, Ficker, O.,, Bilato, R., Bourdelle, C.,, Goniche, M.,, Mantsinen, M., Valisa, M., Baranov, Y.,   +64 more
core   +1 more source

Photoacoustic Laser System for Food Fraud Detection

Sensors, 2021
Economically motivated adulterations of food, in general, and spices, in particular, are an emerging threat to world health. Reliable techniques for the rapid screening of counterfeited ingredients in the supply chain need further development.
Luca Fiorani, Florinda Artuso, Isabella Giardina, Antonia Lai, Simone Mannori, Adriana Puiu   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

A Heuristic Exploration of Zonal Flow-like Structures in the Presence of Toroidal Rotation in a Non-Inertial Frame

Plasma
The mechanisms by which rotation influences zonal flows (ZFs) in plasma are incompletely understood, presenting a significant challenge in the study of plasma dynamics.
Xinliang Xu, Yihang Chen, Yulin Zhou, Zhanhui Wang, Xueke Wu, Bo Li, Jiang Sun, Junzhao Zhang, Da Li   +8 more
doaj   +1 more source