Results 71 to 80 of about 355,529 (299)

Computational modelling of the HyperVapotron cooling technique for nuclear fusion applications [PDF]

, 2010
Efficient heat transfer technologies are essential for magnetically confined fusion reactors; this applies to both the current generation of experimental reactors as well as future power plants.
Milnes, Joseph
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Status of LHFW research in KSTAR and Future Plan [PDF]

EPJ Web of Conferences
The LHFW research has been conducted on KSTAR after successful feasibility study on VEST. With a newly developed SWA (Slotted Waveguide Antenna) of 2.45 GHz, for the first time LHFW experiment was carried out in the 2024 KSTAR campaign.
Kim Sunho, Jo Jonggab, Wi Hyunho, Kim Jeehyun, Wang Sonjong   +4 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Turbulent transport stabilization by ICRH minority fast ions in low rotating JET ILW L-mode plasmas [PDF]

, 2018
The first experimental demonstration that fast ion induced stabilization of thermal turbulent transport takes place also at low values of plasma toroidal rotation has been obtained in JET ILW (ITER-like wall) L-mode plasmas with high ( 3 He)-D ICRH (ion ...
Di Siena, A., P. Mantica, Van Eester, D., Mantica, P., Tsalas, M., C. Giroud, Giroud, C., E. Delabie, Johnson, T., T. Johnson, N. Bonanomi, null null, Bonanomi, N., A. Di Siena, M. Tsalas, D. Van Eester, Delabie, E., S. Menmuir, Johnson, Thomas,, Menmuir, S., E. Lerche, Lerche, E., JET Contributors, Contributors, Jet   +23 more
core   +1 more source

Investigating the metastability of amorphous calcium carbonate by droplet microfluidics experiments using machine learning

Scientific Reports
Amorphous calcium carbonate (ACC) plays an important role in the crystallization pathways of calcite and its polymorphs influencing many natural and anthropogenic processes, such as carbon sequestration.
Ryan Santoso, Lisa Guignon, Guido Deissmann, Jenna Poonoosamy   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

An Archival Study on the Fusion Researches in Japan from 1965 to 1986 An Interview with Sekiguchi Tadashi [PDF]

, 2001
We here report an archival study undertaken by the method of an interview with Sekiguchi Tadashi, Professor Emeritus at the University of Tokyo. The theme covers the circumstances of the fusion research during the period (1965-1976) when fusion project ...
KAWAKAMI, Ichiro, KIMURA, Kazue, UEMATSU, Eisui, TAKAIWA, Yoshinobu, NISIO, Shigeko, OBAYASHI, Haruo, TAKEDA, Tatsuoki, NAMBA, Chusei, NISHIO, Shigeko, FUJITA, Junji, WAKATANI, Masahiro, TERASHIMA, Yoshinosuke   +11 more
core  

Feasibility of non-thermal helium measurements with charge exchange spectroscopy on ITER

, 2012
The use of active charge exchange recombination spectroscopy (CXRS) as a diagnostic for fusion-produced alpha particles on ITER is constrained by the signal-to-noise ratio, which is determined by the intensity of the line of interest, the optical ...
Hellermann, von, M.G., Delabie, E.G., Jaspers, R.J.E., Jaspers, R. J. E., von Hellermann, M. G., Delabie, E., Kappatou, A., von Hellermann, M.G., Jaspers, R.J. E.   +8 more
core   +1 more source