Results 71 to 80 of about 384,818 (233)

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Investigating the metastability of amorphous calcium carbonate by droplet microfluidics experiments using machine learning

Scientific Reports
Amorphous calcium carbonate (ACC) plays an important role in the crystallization pathways of calcite and its polymorphs influencing many natural and anthropogenic processes, such as carbon sequestration.
Ryan Santoso, Lisa Guignon, Guido Deissmann, Jenna Poonoosamy   +3 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Stability analysis of plasma waves driven by runaway electrons in tokamak hot plasmas

Nuclear Fusion
The local stability analysis of plasma waves driven by runaway electrons (REs) has been performed considering hot plasma Maxwellian background, with electron and ion temperatures of the order of 1 keV.
C. Castaldo, L. Della Volpe, R. Fedele, W. Bin, P. Buratti, A. Cardinali, F. Napoli, M. Marinucci, G. Apruzzese, C. Cianfarani, E. Giovannozzi, O. Tudisco   +11 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Physics-based machine learning toolbox for probing concentration under diffusive regime in microfluidics devices

Communications Physics
Microfluidics experiments offer high-resolution insights into transport and chemical processes in porous media, yet direct measurement of evolving concentration profiles remains challenging. Numerical simulations can serve as virtual probes but are labor-
Ryan Santoso, Yuankai Yang, Mara Lönartz, Jenna Poonoosamy   +3 more
doaj   +1 more source

Fusion of radioactive $^{132}$Sn with $^{64}$Ni

, 2007
Evaporation residue and fission cross sections of radioactive $^{132}$Sn on $^{64}$Ni were measured near the Coulomb barrier. A large sub-barrier fusion enhancement was observed.
A. Galindo-Uribarri, A. L. Caraley, C. J. Gross, D. Peterson, D. Shapira, D. W. Stracener, F. James, H. Amro, J. D. Bierman, J. F. Liang, J. Gomez del Campo, J. J. Kolata, J. R. Beene, K. L. Jones, P. A. Hausladen, P. E. Mueller, R. A. Broglia, R. L. Varner, R. Vandenbosch, W. D. Myers, W. Loveland, Y. Larochelle   +21 more
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source