Results 71 to 80 of about 320,326 (253)

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

The efficiency of terahertz radiation generated by two chirped femtosecond laser pulses at different pulse durations

AIP Advances
A high optical-to-terahertz (THz) energy conversion efficiency is essential for the production of high-power ultra-broadband THz waves. In this work, we study the efficiency of THz radiation produced by two chirped femtosecond laser pulses in an air ...
Abdelrahman I. Mahdy, Hoda A. Eltayeb
doaj   +1 more source

You complete me: tumor cell-myeloid cell nuclear fusion as a facilitator of organ-specific metastasis. [PDF]

Front Oncol, 2023
Cozzo AJ, Coleman MF, Hursting SD.
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Speciation and radiation stability of Cr and Ln “Grey-Phases” within Cr-doped (Ln,U)O2 spent fuel model materials

npj Materials Degradation
Cr-doped UO₂ fuels are increasingly adopted for their superior in-reactor performance compared to undoped UO₂, but their spent fuel behaviour, particularly potential Cr speciation and fission product reactivity, remains poorly understood.
Daniil Shirokiy, Andrey Bukaemskiy, Maximilian Henkes, Elena F. Bazarkina, Christoph Hennig, Andrew Ryan, Martina Klinkenberg, Murat Güngör, Mara McCleary, Julien Marquardt, Andrew Fitch, Kristina O. Kvashnina, Dirk Bosbach, Gabriel L. Murphy   +13 more
doaj   +1 more source

Investigation of interfacial strength in nacre-mimicking tungsten heavy alloys for nuclear fusion applications. [PDF]

Sci Rep, 2023
Haag JV, Wang J, Kruska K, Olszta MJ, Henager CH, Edwards DJ, Setyawan W, Murayama M.   +7 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Advances, Challenges, and Future Perspectives of Microwave Reflectometry for Plasma Position and Shape Control on Future Nuclear Fusion Devices. [PDF]

Sensors (Basel), 2023
Gonçalves B, Varela P, Silva A, Silva F, Santos J, Ricardo E, Vale A, Luís R, Nietiadi Y, Malaquias A, Belo J, Dias J, Ferreira J, Franke T, Biel W, Heuraux S, Ribeiro T, De Masi G, Tudisco O, Cavazzana R, Marchiori G, D'Arcangelo O.   +21 more
europepmc   +1 more source