Results 181 to 190 of about 3,070,377 (288)

MPP8 Facilitates DNA DSB Repair via NHEJ to Promote Chemoresistance of TNBC Independent of Methyl‐H3K9 Binding

Advanced Science, EarlyView.
Chemoresistance is often linked to elevated DNA repair. MPP8 is found to promote breast cancer chemoresistance as a novel NHEJ accessory factor independent of its epigenetic functions. Through multiple protein interactions, MPP8 facilitates association of DNAPK and ligase complexes to promote DNA repair progression.
Rupa Kumari, Jia Fang
wiley   +1 more source

Optimally controlled nuclear magnetic resonance (NMR) in electrochemistry: Larmor versus nutation frequency selective spin excitation for locally selective NMR experiments. [PDF]

Magn Reson (Gott)
Kochs JF, Römer AJ, Schatz M, Streun M, Jovanovic S, Eichel RA, Köcher SS, Granwehr J.   +7 more
europepmc   +1 more source

Tumor‐Intrinsic HEXB Drives Endothelial‐To‐Mesenchymal Transition and Confers Resistance to Anti‐Angiogenic Therapy in Glioblastoma

Advanced Science, EarlyView.
This study elucidates how glioblastoma tumors develop resistance to anti‐VEGF therapy through endothelial‐to‐mesenchymal transition (Endo‐MT). The researchers identify a novel signaling pathway where tumor‐derived HEXB stabilizes HSP60 to drive this vascular reprogramming.
Tianqi Liu, Xin Chen, Tao Sun, Jianqi Wu, Haixu Yan, Xing Liu, Hongda Lin, Xiangyu Wang, Ziao Xiao, Yang Xu, Qiang Fu, Peng Cheng, Wen Cheng, Anhua Wu   +13 more
wiley   +1 more source

Manufacturing of LDPE-Based Shields and Exposure in LEO Environment in the MISSE9 Campaign. [PDF]

Polymers (Basel)
Bellisario D, Proietti A, Iorio L, Quadrini F, Santo L.   +4 more
europepmc   +1 more source

Ionically Counter‐Programmable Phase‐Separation of Superstable Star‐Biopolyamide Coacervates for Electrothermally‐Responsive Pseudosolid Smart Windows

Advanced Science, EarlyView.
We develop bio‐based, star‐branched polyamides from itaconic acid and cadaverine with tunable lower critical solution temperature (LCST) transitions for dynamic solar modulation. Specific metal ion coordination with pyrrolidone moieties drives precise phase transitions via calcium‐induced salting‐in and sodium‐induced salting‐out mechanisms. Formulated
Jie Liu, Xiaotian Zhu, Jinjian Hou, Jinze Du, Mohammad Asif Ali, Maiko K. Okajima, Tatsuo Kaneko   +6 more
wiley   +1 more source

Link between Spin-Orbit Relativity and Magnetically Induced Current Densities in Heavy-Atom Hydrides: <i>trans</i>-Ligand Influence. [PDF]

JACS Au
Blasco D, Novotný J, Asher JR, Berger RJF, Komorovsky S, Marek R.   +5 more
europepmc   +1 more source

Sub‐Second Ratiometric Fluorescence Imaging of Histamine Dynamics in Living Cells via a Supramolecular Probe

Advanced Science, EarlyView.
A tailored tripartite supramolecular ratiometric probe, engineered by modulating the fluorogenic guest's cationic locus, enables ultrafast histamine monitoring in living cells. Utilizing a competitive displacement mechanism, this system achieves a sub‐second response time with high selectivity.
Chenming Chan, Yujie Han, Yu‐Fei Song, Chunlei Jiang, Qi‐Wei Zhang   +4 more
wiley   +1 more source

Conformational Switching Controls Biradical Spin Dynamics in Flavin-Tryptophan Dyads. [PDF]

J Am Chem Soc
Musabirova G, Morozova OB, Kiryutin AS, Anisimova IS, Zhukov IV, Theiss T, Gerhards L, Zoller BGE, Gulder T, Matysik J, Solov'yov IA, Yurkovskaya AV.   +11 more
europepmc   +1 more source

VCP‐Regulated LMF2 Stabilizes the Cholesterol Biosynthesis Enzyme HMGCS1 to Drive Cancer Progression and Confer Capecitabine Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
LMF2 drives progression and capecitabine resistance in triple‐negative breast cancer (TNBC). Mechanistically, VCP prevents NBR1‐mediated autophagic degradation of LMF2, thereby stabilizing it. Stabilized LMF2 subsequently suppresses NDP52‐mediated autophagic degradation of HMGCS1, a rate‐limiting cholesterol biosynthesis enzyme.
Qian Zhao, Lisa Andriani, Yin‐Ling Zhang, Shao‐Ying Yang, Yun‐Xiao Ling, Min‐Ying Huang, Jia‐Yang Cai, Fang‐Lin Zhang, Xin Hu, A‐Yong Cao, Zhi‐Min Shao, Guang‐Yu Liu, Da‐Qiang Li   +12 more
wiley   +1 more source

Remaining Life Prediction of Shielding Sleeves Based on Data Augmentation and Hybrid Models. [PDF]

Sensors (Basel)
Zhang X, Xiang X, Li H, Liu N, Chen Z.
europepmc   +1 more source