Results 1 to 10 of about 1,791,306 (268)

Nuclear Dipole Moments and Shielding Constants of Light Nuclei Measured in Magnetic Fields

Magnetochemistry, 2023
Nuclear magnetic resonance (NMR) is a branch of spectroscopy commonly used for identifying the chemical structure of various materials. One of the areas in which NMR provides accurate data is the determination of nuclear magnetic moments.
Włodzimierz Makulski, Mateusz A. Słowiński, Piotr Garbacz   +2 more
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Glutamate and GABA Homeostasis and Neurometabolism in Major Depressive Disorder

Frontiers in Psychiatry, 2021
Major depressive disorder (MDD) is a leading cause of distress, disability, and suicides. As per the latest WHO report, MDD affects more than 260 million people worldwide.
Ajay Sarawagi, Ajay Sarawagi, Narayan Datt Soni, Anant Bahadur Patel, Anant Bahadur Patel   +4 more
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Characterization of a fold in TANGO1 evolved from SH3 domains for the export of bulky cargos

Nature Communications, 2023
Bulky cargos like procollagens, apolipoproteins, and mucins exceed the size of conventional COPII vesicles. During evolution a process emerged in metazoans, predominantly governed by the TANGO1 protein family, that organizes cargo at the exit sites of ...
Oliver Arnolds, Raphael Stoll
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Searching for the Best Values of NMR Shielding and Spin-Spin Coupling Parameters: CH_4-nF_n Series of Molecules as the Example

Molecules, 2023
Attempts at the theoretical interpretation of NMR spectra have a very long and fascinating history. Present quantum chemical calculations of shielding and indirect spin-spin couplings permit modeling NMR spectra when small, isolated molecules are studied.
Karol Jackowski, Mateusz A. Słowiński
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Revising the mechanism of p75NTR activation: intrinsically monomeric state of death domains invokes the "helper" hypothesis

Scientific Reports, 2020
The neurotrophin receptor p75NTR plays crucial roles in neuron development and regulates important neuronal processes like degeneration, apoptosis and cell survival. At the same time the detailed mechanism of signal transduction is unclear.
Sergey A. Goncharuk, Lilya E. Artemieva, Kirill D. Nadezhdin, Alexander S. Arseniev, Konstantin S. Mineev   +4 more
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Enantiotropy of Simvastatin as a Result of Weakened Interactions in the Crystal Lattice: Entropy-Driven Double Transitions and the Transient Modulated Phase as Seen by Solid-State NMR Spectroscopy

Molecules, 2022
In crystalline molecular solids, in the absence of strong intermolecular interactions, entropy-driven processes play a key role in the formation of dynamically modulated transient phases.
Jiri Brus, Jiri Czernek, Martina Urbanova, Ctirad Červinka   +3 more
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Energetics of Excitatory and Inhibitory Neurotransmission in Aluminum Chloride Model of Alzheimer’s Disease: Reversal of Behavioral and Metabolic Deficits by Rasa Sindoor

Frontiers in Molecular Neuroscience, 2017
Alzheimer’s disease (AD) is an age-related neurodegenerative disorder, characterized by progressive loss of cognitive functions and memory. Excessive intake of aluminum chloride in drinking water is associated with amyloid plaques and neurofibrillary ...
Kamal Saba, Niharika Rajnala, Pandichelvam Veeraiah, Vivek Tiwari, Rohit K. Rana, Subhash C. Lakhotia, Anant B. Patel   +6 more
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A distinct mechanism of C-type inactivation in the Kv-like KcsA mutant E71V

Nature Communications, 2022
Constriction of the selectivity filter is assumed to be a hallmark of C-type inactivation in K+ channels. Using different high-resolution methods, this study shows a distinct C-type inactivation mechanism in a KcsA mutant that emulates Kv-channels.
Ahmed Rohaim, Bram J. A. Vermeulen, Jing Li, Felix Kümmerer, Federico Napoli, Lydia Blachowicz, João Medeiros-Silva, Benoît Roux, Markus Weingarth   +8 more
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Formation of the β-barrel assembly machinery complex in lipid bilayers as seen by solid-state NMR

Nature Communications, 2018
The β-barrel assembly machinery (BAM) catalyzes β-barrel protein insertion into the outer membrane of E.coli. Here authors employ high-sensitivity solid-state NMR to reveal how the lipid environment and formation of the BamA-BamCDE complex affect BamA ...
Cecilia Pinto, Deni Mance, Tessa Sinnige, Mark Daniëls, Markus Weingarth, Marc Baldus   +5 more
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Regulation of the Target of Rapamycin and Other Phosphatidylinositol 3-Kinase-Related Kinases by Membrane Targeting

Membranes, 2015
Phosphatidylinositol 3-kinase-related kinases (PIKKs) play vital roles in the regulation of cell growth, proliferation, survival, and consequently metabolism, as well as in the cellular response to stresses such as ionizing radiation or redox changes. In
Maristella De Cicco, Munirah S. Abd Rahim, Sonja A. Dames   +2 more
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