Results 1 to 10 of about 309,964 (310)

Molecular action of NZ2114, a superior plectasin derivative

npj Antimicrobials and Resistance
NZ2114 is a triple-mutant of the natural peptide antibiotic plectasin that targets the peptidoglycan precursor molecule Lipid II using a supramolecular action, involving assembly of plectasin-Lipid II complexes in a large oligomeric structure, that is ...
Maik G. N. Derks, Shehrazade Jekhmane, Sourav Maity, Vicky Charitou, Cornelis J. Slingerland, Benjamin Vermeer, Mick van der Weijde, Charalampos Ntallis, Nathaniel I. Martin, Wouter H. Roos, Eefjan Breukink, Markus Weingarth   +11 more
doaj   +1 more source

Brevibacillin 2V, a Novel Antimicrobial Lipopeptide With an Exceptionally Low Hemolytic Activity

Frontiers in Microbiology, 2021
Bacterial non-ribosomally produced peptides (NRPs) form a rich source of antibiotics, including more than 20 of these antibiotics that are used in the clinic, such as penicillin G, colistin, vancomycin, and chloramphenicol.
Xinghong Zhao, Xiaoqi Wang, Rhythm Shukla, Rhythm Shukla, Raj Kumar, Markus Weingarth, Eefjan Breukink, Oscar P. Kuipers   +7 more
doaj   +1 more source

A NMR guided approach for CsrA–RNA crystallization

, 2013
Structure determination of protein–nucleic acid complexes remains a challenging task. Here we present a simple method for generating crystals of a CsrA–nucleic acid complex, guided entirely by results from nuclear magnetic resonances spectroscopy (NMR ...
NMR Spectroscopy, Kaptein, R., Gronenborn, A.M., Sub NMR Spectroscopy, Boelens, R., Koharudin, L.M.I.   +5 more
core   +1 more source

Brevibacillin 2V Exerts Its Bactericidal Activity via Binding to Lipid II and Permeabilizing Cellular Membranes

Frontiers in Microbiology, 2021
Lipo-tridecapeptides, a class of bacterial non-ribosomally produced peptides, show strong antimicrobial activity against Gram-positive pathogens, including antibiotic-resistant Staphylococcus aureus and Enterococcus spp.
Xinghong Zhao, Xiaoqi Wang, Rhythm Shukla, Rhythm Shukla, Raj Kumar, Markus Weingarth, Eefjan Breukink, Oscar P. Kuipers   +7 more
doaj   +1 more source

Probing molecular motion by double-quantum (13C,13C) solid-state NMR spectroscopy: Application to ubiquitin

, 2010
We demonstrate the use of two-dimensional (13C,13C) double-quantum spectroscopy to detect molecular dynamics by solid-state NMR. Data collected on tyrosine-ethylester (TEE) are in line with previously determined (1H,13C) order parameters.
NMR Spectroscopy, Baldus, M., Seidel, K., Schneider, R., Etzkorn, M., Becker, S., Sub NMR Spectroscopy, de Lange, A., Lange, A.   +8 more
core   +1 more source

Fractional Deuteration applied to biomolecular solid-state NMR spectroscopy [PDF]

, 2011
Solid-state Nuclear Magnetic Resonance can provide detailed insight into structural and dynamical aspects of complex biomolecules. With increasing molecular size, advanced approaches for spectral simplification and the detection of medium to long-range ...
NMR Spectroscopy, Baldus, M., Cukkemane, A.A., Deepak Nand, Abhishek Cukkemane, Nand, D., Becker, S., Stefan Becker, Sub NMR Spectroscopy, Cukkemane, A., Marc Baldus   +10 more
core   +1 more source

Characterization of a Cyclic Nucleotide-Activated K+ Channel and its Lipid Environment by Using Solid-State NMR Spectroscopy

, 2013
Voltage-gated ion channels are large tetrameric multidomain membrane proteins that play crucial roles in various cellular transduction pathways. Because of their large size and domain-related mobility, structural characterization has proved challenging ...
NMR Spectroscopy, Baldus, M., Cukkemane, A.A., Sub NMR Spectroscopy   +3 more
core   +1 more source

Structural rearrangements of membrane proteins probed by water-edited solid-state NMR spectroscopy

, 2009
We show that water-edited solid-state NMR spectroscopy allows for probing global protein conformation and residue-specific solvent accessibility in a lipid bilayer environment.
Ader, C., NMR Spectroscopy, Baldus, M., Seidel, K., Schneider, R., Etzkorn, M., Becker, S., Sub NMR Spectroscopy, Dep Scheikunde   +8 more
core   +1 more source

Nuclear Magnetic Resonance Detects Phosphoinositide 3-Kinase/Akt-Independent Traits Common to Pluripotent Murine Embryonic Stem Cells and Their Malignant Counterparts

Neoplasia: An International Journal for Oncology Research, 2009
Pluripotent embryonic stem (ES) cells, a potential source of somatic precursors for cell therapies, cause tumors after transplantation. Studies of mammalian carcinogenesis using nuclear magnetic resonance (NMR) spectroscopy have revealed changes in the ...
Hanna M. Romanska, Stefano Tiziani, Rachael C. Howe, Ulrich L. Günther, Zulfiqar Gulzar, El-Nasir Lalani   +5 more
doaj   +1 more source

A structural and dynamic visualization of the interaction between MAP7 and microtubules

Nature Communications
Microtubules (MTs) are key components of the eukaryotic cytoskeleton and are essential for intracellular organization, organelle trafficking and mitosis. MT tasks depend on binding and interactions with MT-associated proteins (MAPs).
Agnes Adler, Mamata Bangera, J. Wouter Beugelink, Salima Bahri, Hugo van Ingen, Carolyn A. Moores, Marc Baldus   +6 more
doaj   +1 more source