Results 41 to 50 of about 309,964 (310)
Kinetic Analysis of Protein Aggregation Monitored by Real-Time 2D Solid-State NMR Spectroscopy [PDF]
, 2011 It is shown that real-time 2D solid-state NMR can be used to obtain kinetic and structural information about the process of protein aggregation. In addition to the incorporation of kinetic information involving intermediate states, this approach can ...
Baldus, Marc +11 more
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NeurogliaElectroconvulsive therapy (ECT) is an effective treatment for severe and drug-resistant depression, yet its mode of action remains poorly understood.
Ajay Sarawagi +5 more
doaj +1 more source
A comprehensive framework of E2–RING E3 interactions of the human ubiquitin–proteasome system
Molecular Systems Biology, 2009 Covalent attachment of ubiquitin to substrates is crucial to protein degradation, transcription regulation and cell signalling. Highly specific interactions between ubiquitin‐conjugating enzymes (E2) and ubiquitin protein E3 ligases fulfil essential ...
Sjoerd J L van Wijk +6 more
doaj +1 more source
NMR Spectroscopy for Metabolomics Research [PDF]
Metabolites, 2019 Over the past two decades, nuclear magnetic resonance (NMR) has emerged as one of the three principal analytical techniques used in metabolomics (the other two being gas chromatography coupled to mass spectrometry (GC-MS) and liquid chromatography coupled with single-stage mass spectrometry (LC-MS)). The relative ease of sample preparation, the ability
Abdul-Hamid Emwas +10 more
openaire +5 more sources
High-resolution NMR studies of antibiotics in cellular membranes
Nature Communications, 2018 Antibiotics that target the peptidoglycan precursor lipid II are promising templates for next-generation antibiotics. Here authors use solid-state NMR and monitor lipid II-binding antibiotics, such as nisin, directly in cell membranes.
João Medeiros-Silva +7 more
doaj +1 more source
CASD-NMR: critical assessment of automated structure determination by NMR
, 2009 NMR spectroscopy is currently the only technique for determining the solution structure of biological macromolecules. This typically requires both the assignment of resonances and a labor-intensive analysis of multidimensional nuclear Overhauser effect ...
NMR Spectroscopy +4 more
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Early Stage Diagnosis of Oral Cancer Using 1H NMR–Based Metabolomics
Neoplasia: An International Journal for Oncology Research, 2009 Oral cancer is the eighth most common cancer worldwide and represents a significant disease burden. If detected at an early stage, survival from oral cancer is better than 90% at 5 years, whereas late stage disease survival is only 30%.
Stefano Tiziani +2 more
doaj +1 more source
Nature Communications, 2020 Microtubule (MT) organization is regulated by many microtubule-associated proteins (MAPs) that contain intrinsically disordered regions. Here authors produce [13C, 15N] labeled, functional microtubules from human cells for solid-state NMR which allows ...
Yanzhang Luo +8 more
doaj +1 more source
Characterization of membrane protein function by solid-state NMR spectroscopy
, 2014 Membrane proteins are an important class of biological molecules whose association with lipid bilayers and intrinsic molecular mobility can complicate their structural study by high-resolution methods.
Baldus, Marc +3 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source