Results 21 to 30 of about 309,964 (310)

Diffusion NMR spectroscopy [PDF]

NMR in Biomedicine, 2001
AbstractMR offers unique tools for measuring molecular diffusion. This review focuses on the use of diffusion‐weighted MR spectroscopy (DW‐MRS) to non‐invasively quantitate the translational displacement of endogenous metabolites in intact mammalian tissues.
Nicolay, K., Braun, K.P.J., Graaf, de, R.A., Dijkhuizen, R.M., Kruiskamp, M.J.   +4 more
openaire   +2 more sources

Binding hotspots of BAZ2B bromodomain:histone interaction revealed by solution NMR driven docking [PDF]

, 2014
Bromodomains are epigenetic reader domains, which have come under increasing scrutiny both from academic and pharmaceutical research groups. Effective targeting of the BAZ2B bromodomain by small molecule inhibitors has been recently reported, but no ...
Ferguson, Fleur M., Alexandre M. J. J. Bonvin (18079), Alexandre M. J. J. Bonvin, João P. G. L. M. Rodrigues (1312506), Wienk, Hans, Fleur M. Ferguson (1304613), Rolf Boelens (18078), Alessio Ciulli, Boelens, Rolf, NMR Spectroscopy, Chris Abell, Fleur M. Ferguson, Garcia Lopes Maia Rodrigues, João, Rodrigues, João P. G. L. M., David M. Dias, Bonvin, Alexandre M. J. J., Sub NMR Spectroscopy, Dias, David M., João P. G. L. M. Rodrigues, David M. Dias (1340694), Rolf Boelens, Abell, Chris, Hans Wienk (684663), Ciulli, Alessio, Hans Wienk, Chris Abell (197099), Alessio Ciulli (762789)   +26 more
core   +1 more source

Revising the mechanism of p75NTR activation: intrinsically monomeric state of death domains invokes the "helper" hypothesis

Scientific Reports, 2020
The neurotrophin receptor p75NTR plays crucial roles in neuron development and regulates important neuronal processes like degeneration, apoptosis and cell survival. At the same time the detailed mechanism of signal transduction is unclear.
Sergey A. Goncharuk, Lilya E. Artemieva, Kirill D. Nadezhdin, Alexander S. Arseniev, Konstantin S. Mineev   +4 more
doaj   +1 more source

Enantiotropy of Simvastatin as a Result of Weakened Interactions in the Crystal Lattice: Entropy-Driven Double Transitions and the Transient Modulated Phase as Seen by Solid-State NMR Spectroscopy

Molecules, 2022
In crystalline molecular solids, in the absence of strong intermolecular interactions, entropy-driven processes play a key role in the formation of dynamically modulated transient phases.
Jiri Brus, Jiri Czernek, Martina Urbanova, Ctirad Červinka   +3 more
doaj   +1 more source

Energetics of Excitatory and Inhibitory Neurotransmission in Aluminum Chloride Model of Alzheimer’s Disease: Reversal of Behavioral and Metabolic Deficits by Rasa Sindoor

Frontiers in Molecular Neuroscience, 2017
Alzheimer’s disease (AD) is an age-related neurodegenerative disorder, characterized by progressive loss of cognitive functions and memory. Excessive intake of aluminum chloride in drinking water is associated with amyloid plaques and neurofibrillary ...
Kamal Saba, Niharika Rajnala, Pandichelvam Veeraiah, Vivek Tiwari, Rohit K. Rana, Subhash C. Lakhotia, Anant B. Patel   +6 more
doaj   +1 more source

A distinct mechanism of C-type inactivation in the Kv-like KcsA mutant E71V

Nature Communications, 2022
Constriction of the selectivity filter is assumed to be a hallmark of C-type inactivation in K+ channels. Using different high-resolution methods, this study shows a distinct C-type inactivation mechanism in a KcsA mutant that emulates Kv-channels.
Ahmed Rohaim, Bram J. A. Vermeulen, Jing Li, Felix Kümmerer, Federico Napoli, Lydia Blachowicz, João Medeiros-Silva, Benoît Roux, Markus Weingarth   +8 more
doaj   +1 more source

Formation of the β-barrel assembly machinery complex in lipid bilayers as seen by solid-state NMR

Nature Communications, 2018
The β-barrel assembly machinery (BAM) catalyzes β-barrel protein insertion into the outer membrane of E.coli. Here authors employ high-sensitivity solid-state NMR to reveal how the lipid environment and formation of the BamA-BamCDE complex affect BamA ...
Cecilia Pinto, Deni Mance, Tessa Sinnige, Mark Daniëls, Markus Weingarth, Marc Baldus   +5 more
doaj   +1 more source

Regulation of the Target of Rapamycin and Other Phosphatidylinositol 3-Kinase-Related Kinases by Membrane Targeting

Membranes, 2015
Phosphatidylinositol 3-kinase-related kinases (PIKKs) play vital roles in the regulation of cell growth, proliferation, survival, and consequently metabolism, as well as in the cellular response to stresses such as ionizing radiation or redox changes. In
Maristella De Cicco, Munirah S. Abd Rahim, Sonja A. Dames   +2 more
doaj   +1 more source

Atomic-level insight into mRNA processing bodies by combining solid and solution-state NMR spectroscopy

Nature Communications, 2019
Processing bodies are membrane less organelles that contain enzymes involved in mRNA turnover, among them enhancer of decapping 3 (Edc3). Here the authors use solid- and solution-state NMR spectroscopy to characterize the structural organization and ...
Reinier Damman, Stefan Schütz, Yanzhang Luo, Markus Weingarth, Remco Sprangers, Marc Baldus   +5 more
doaj   +1 more source

Characterization of the cell wall of a mushroom forming fungus at atomic resolution using solid-state NMR spectroscopy

The Cell Surface, 2020
Cell walls are essential in the interaction of fungi with the (a)biotic environment and are also key to hyphal morphogenesis and mechanical strength. Here, we used solid-state NMR (ssNMR) spectroscopy combined with HPLC and GC–MS to study the structural ...
Helena Leona Ehren, Freek V.W. Appels, Klaartje Houben, Marie A.M. Renault, Han A.B. Wösten, Marc Baldus   +5 more
doaj   +1 more source