Results 31 to 40 of about 340,947 (357)

Structural rearrangements of membrane proteins probed by water-edited solid-state NMR spectroscopy [PDF]

, 2009
We show that water-edited solid-state NMR spectroscopy allows for probing global protein conformation and residue-specific solvent accessibility in a lipid bilayer environment.
Ader, C., NMR Spectroscopy, Baldus, M., Seidel, K., Schneider, R., Etzkorn, M., Becker, S., Sub NMR Spectroscopy, Dep Scheikunde   +8 more
core   +1 more source

Shifts in the selectivity filter dynamics cause modal gating in K+ channels

Nature Communications, 2019
Spontaneous activity shifts at constant experimental conditions are widespread among ion channels but the molecular origins are poorly understood. Here, using solid-state NMR and MD simulations, the authors reveal that modal gating shifts in K + channels
Shehrazade Jekhmane, João Medeiros-Silva, Jing Li, Felix Kümmerer, Christoph Müller-Hermes, Marc Baldus, Benoît Roux, Markus Weingarth   +7 more
doaj   +1 more source

Biological solid-state NMR: Integrative across different scientific disciplines

Journal of Structural Biology: X, 2022
For almost five decades, solid-state NMR (ssNMR) has been used to study complex biomolecular systems. This article gives a view on how ssNMR methods and applications have evolved during this time period in a broader structural biology context.
Marc Baldus
doaj   +1 more source

Nuclear magnetic resonance (NMR) applied to membrane-protein complexes [PDF]

, 2016
Increasing evidence suggests that most proteins occur and function in complexes rather than as isolated entities when embedded in cellular membranes.
Baldus, Marc, NMR Spectroscopy, Sub NMR Spectroscopy, Kaplan, M., Houben, Klaartje, de Agrela Pinto, Cecilia   +5 more
core   +1 more source

Mode of action of teixobactins in cellular membranes

Nature Communications, 2020
The natural antibiotic teixobactin kills bacteria by direct binding to their cognate cell wall precursors (Lipid II and III). Here authors use solid-state NMR to reveal the native binding mode of teixobactins and show that teixobactins only weakly bind ...
Rhythm Shukla, João Medeiros-Silva, Anish Parmar, Bram J. A. Vermeulen, Sanjit Das, Alessandra Lucini Paioni, Shehrazade Jekhmane, Joseph Lorent, Alexandre M. J. J. Bonvin, Marc Baldus, Moreno Lelli, Edwin J. A. Veldhuizen, Eefjan Breukink, Ishwar Singh, Markus Weingarth   +14 more
doaj   +1 more source

Binding of micro-nutrients to the cell wall of the fungus Schizophyllum commune

The Cell Surface, 2023
The cell wall fulfils several functions in the biology of fungi. For instance, it provides mechanical strength, interacts with the (a)biotic environment, and acts as a molecular sieve.
Fleur E.L. Kleijburg, Adil A. Safeer, Marc Baldus, Han A.B. Wösten   +3 more
doaj   +1 more source

NMR characterization of foldedness for the production of E3 RING domains [PDF]

, 2010
We summarize the use of NMR spectroscopy in the production and the screening of stability and foldedness of protein domains, and apply it to the RING domains of E3 ubiquitin-ligases.
NMR Spectroscopy, Folkers, G.E., Huang, A., Sub NMR Spectroscopy, Boelens, R., Dep Scheikunde, de Jong, R.N.   +6 more
core   +1 more source

Structural Changes of Sodium Warfarin in Tablets Affecting the Dissolution Profiles and Potential Safety of Generic Substitution

Pharmaceutics, 2021
At present, the risk of generic substitutions in warfarin tablets is still being discussed. The aim of this study was to assess whether API interactions with commonly used excipients may affect the safety of generic replacement of warfarin sodium tablets.
Jan Muselík, Martina Urbanova, Eva Bartoníčková, Jakub Palovčík, David Vetchý, Jiří Czernek, Larisa Janisova, Nadiia Velychkivska, Aleš Franc, Jiří Brus   +9 more
doaj   +1 more source

Kinetic Analysis of Protein Aggregation Monitored by Real-Time 2D Solid-State NMR Spectroscopy [PDF]

, 2011
It is shown that real-time 2D solid-state NMR can be used to obtain kinetic and structural information about the process of protein aggregation. In addition to the incorporation of kinetic information involving intermediate states, this approach can ...
Baldus, Marc, Manuel Etzkorn, NMR Spectroscopy, Bockmann, Anja, Baldus, M., Anja Böckmann, Etzkorn, M., Böckmann, A., Etzkorn, Manuel, Sub NMR Spectroscopy, Boeckmann, A., Marc Baldus   +11 more
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Impacts of Electroconvulsive Therapy on the Neurometabolic Activity in a Mice Model of Depression: An Ex Vivo ¹H-[¹³C]-NMR Spectroscopy Study

Neuroglia
Electroconvulsive therapy (ECT) is an effective treatment for severe and drug-resistant depression, yet its mode of action remains poorly understood.
Ajay Sarawagi, Pratishtha Wadnerkar, Vrundika Keluskar, Narra Sai Ram, Jerald Mahesh Kumar, Anant Bahadur Patel   +5 more
doaj   +1 more source