Results 91 to 100 of about 199,440 (313)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Probing nuclear matter with dileptons [PDF]

, 1986
Dileptons are shown to be of interest in helping probe extreme conditions of temperature and density in nuclear matter. The current state of experimental knowledge about dileptons is briefly described, and their use in upcoming experiments with light ...
Schroeder, L. S., Schroeder, L.S.
core  

From asymmetric nuclear matter to neutron stars: A functional renormalization group study

, 2015
A previous study of nuclear matter in a chiral nucleon-meson model is extended to isospin-asymmetric matter. Fluctuations beyond mean-field approximation are treated in the framework of the functional renormalization group.
Drews, Matthias, Weise, Wolfram
core   +1 more source

Nucleon decays into three leptons: Noncontact contributions

Physics Letters B
We investigate baryon number violating (BNV) nucleon decays into three leptons from noncontact contributions that are induced by dimension-6 (dim-6) BNV operators in low-energy effective field theory (LEFT) with an exchange of a baryon, meson, lepton, or
Jing Chen, Yi Liao, Xiao-Dong Ma, Hao-Lin Wang   +3 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Phonon-mediated Nuclear Excitation Transfer

, 2018
Excitation transfer has long been of interest in biophysics, where electronic excitation is transferred from one location to another mediated by photon exchange.
Hagelstein, Peter L
core  

Nucleon decays into three leptons: contact contributions

Journal of High Energy Physics
Baryon number violating (BNV) nucleon decays into three leptons provide a unique probe of BNV interactions beyond the conventional two-body modes involving a single lepton and a light meson.
Yi Liao, Xiao-Dong Ma, Xiang Zhao
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Theoretical Study of High-Frequency Response of InGaAs/AlAs Double-Barrier Nanostructures

Advances in Materials Science and Engineering, 2017
The presented article contains the numerical calculations of the InGaAs/AlAs resonant tunneling diode’s (RTD) response to the AC electric field of a wide range of amplitudes and frequencies.
Konstantin S. Grishakov, Vladimir F. Elesin, Mikhail M. Maslov, Konstantin P. Katin   +3 more
doaj   +1 more source