Results 111 to 120 of about 199,440 (313)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Asymmetric nuclear matter equation of state

, 1991
Systematic calculations of asymmetric nuclear matter have been performed in the framework of the Brueckner-Bethe-Goldstone approach in a wide range of both density and asymmetry parameter.
BOMBACI, IGNAZIO, LOMBARDO U.
core   +1 more source

Quasi-elastic processes of the 48Ca + 120Sn system and the 48Ca nuclear matter density [PDF]

, 2013
We present the results of a high-precision quasi-elastic excitation function measurement for the 48Ca + 120Sn system at θLAB = 160 at near-barrier energies in steps of 1.0 MeV. The corresponding quasi-elastic barrier distribution is derived.
González Álvarez, Marcos Aurelio, Abou-Haïdar, Z., Huiza, J. F.P., Lubián, Jesus Rios, Crema, Edilson, Medina, Nilberto Heder, Fernández Martínez, Begoña, Faria, Pedro Neto de, Verney, David, Gasques, L. R., Gomes, Paulo Roberto Silveira   +10 more
core   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Transverse and Zero Degree Energies Observed in sub 16/O Induced Nuclear Collisions at 60 and 200 A GeV [PDF]

, 1987
Results from QCD calculations indicate that a sufficiently high energy densities, nuclear matter may undergo a transition to a phase in which quarks and gluons are deconfined.
Young, G. R., Johnson, J. W., Gustafsson, H. A., Lund, I., Schmidt, H. R., Ferguson, R. L., Purschke, M., Kristiansson, P., Plasil, F., Beckmann, P., Poskanzer, A. M., Oskarsson, A., Baktash, C., Santo, R., Persson, S., Siemiarczuk, T., Lohner, H., Awes, T. C., Sorensen, S. P., Glasow, R., Berger, F., Bock, R., Claessen, G., Albrecht, R., Otterlund, I., Kampert, K. H., Obenshain, F. E., Peitzmann, T., Dragon, L., Kolb, B. W., Ritter, H. G., Franz, A., Lee, I. Y., Stenlund, E., Gutbrod, H. H., Garpman, S.   +35 more
core  

Accurate evaluation of molecular potential energy functions through vibrational quantum defect analysis

Scientific Reports
We propose the use of the vibrational quantum defect (VQD) to select the best energy function that could better model the vibrational energy levels of diatomic molecules.We report an analysis of accurate experimental RKR energy data obtained from ...
Haikel Jelassi, Ridha Horchani, Amira Zaouak   +2 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Jets of nuclear matter from high energy heavy ion collisions

, 1980
The nuclear fluid dynamical model with final thermal breakup is used to study the reactions {sup 20}Ne + {sup 238}U and {sup 40}Ar + {sup 40}Ca at E{sub LAB} = 390 MeV/n. The calculated double differential cross sections d{sup 2}{sigma}/d{Omega}dE are in
Csernai, L., Graebner, G., Csernai, L.P., Greiner, W., Maruhn, J., Csernai, L. P., Maruhn, J.A., Kruse, H., Stöcker, H., Buchwald, G., Cusson, R.Y., Maruhn, J. A., Cusson, R. Y., Cusson, R.   +13 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source