Results 121 to 130 of about 1,023,868 (347)
Molecular Oncology, EarlyView.Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh +5 more
wiley +1 more source
Nuclear shock waves in heavy-ion collisions [PDF]
, 2006 It is shown that nuclear matter is compressed during the encounter of heavy ions. If the relative velocity of the nuclei is larger than the velocity of first sound in nuclear matter (compression sound for isospin T=0), nuclear shock waves occur.
Greiner, Walter +2 more
core
Nuclear Lattice Simulations with EFT
, 2004 This proceedings article is a summary of results from work done in collaboration with Bugra Borasoy and Thomas Schaefer. We study nuclear and neutron matter by combining chiral effective field theory with non-perturbative lattice methods.
Beane +15 more
core +1 more source
Conformation dependent electronic transport in a DNA double-helix
AIP Advances, 2015 We present a tight-binding study of conformation dependent electronic transport properties of DNA double-helix including its helical symmetry. We have studied the changes in the localization properties of DNA as we alter the number of stacked bases ...
Sourav Kundu, S. N. Karmakar
doaj +1 more source
Molecular Oncology, EarlyView.RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha +10 more
wiley +1 more source
, 2017 We establish a relation between the equation of state (EOS) of nuclear matter and the fourth-order symmetry energy $a_{\rm{sym,4}}(A)$ of finite nuclei in a semi-empirical nuclear mass formula by self-consistently considering the bulk, surface and ...
Chen, Lie-Wen, Wang, Rui
core +2 more sources
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Towards a holographic quark-hadron continuity
, 2019 We study dense nuclear and quark matter within a single microscopic approach, namely the holographic Sakai-Sugimoto model. Nuclear matter is described via instantons in the bulk, and we show that instanton interactions are crucial for a continuous ...
Fadafan, Kazem Bitaghsir +2 more
core +1 more source
Decrypting cancer's spatial code: from single cells to tissue niches
Molecular Oncology, EarlyView.Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik +4 more
wiley +1 more source
The Range and the Mean Free Path of High Energy Nucleons in Nuclear Matter [PDF]
, 1950 Y. Fujimoto, Y. Yamaguchi
openalex +1 more source