Results 161 to 170 of about 4,373,503 (314)

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Hadrons in Nuclear Matter

EPJ Web of Conferences, 2017
We review the achievements of the project B.5, that deals with the calculation of in-medium properties of vector mesons and an analysis of their experimental signals, with a particular emphasis on the ω photoproduction data from CBELSA/TAPS. Other topics addressed include color transparency, pion electroproduction on nucleons, the Primakoff effect for ...
openaire   +3 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Revalidation of the isobaric multiplet mass equation at A=53, T=3/2

Physics Letters B, 2016
The T=3/2 isobaric analog state (IAS) in 53Co is firmly established through a comprehensive measurement of β-delayed γ and proton decay of 53Ni. The determined excitation energy of 53Co IAS combined with the mass of 53Co generates a precise mass excess ...
J. Su, W.P. Liu, N.T. Zhang, Y.P. Shen, Y.H. Lam, N.A. Smirnova, M. MacCormick, J.S. Wang, L. Jing, Z.H. Li, Y.B. Wang, B. Guo, S.Q. Yan, Y.J. Li, S. Zeng, G. Lian, X.C. Du, L. Gan, X.X. Bai, Z.C. Gao, Y.H. Zhang, X.H. Zhou, X.D. Tang, J.J. He, Y.Y. Yang, S.L. Jin, P. Ma, J.B. Ma, M.R. Huang, Z. Bai, Y.J. Zhou, W.H. Ma, J. Hu, S.W. Xu, S.B. Ma, S.Z. Chen, L.Y. Zhang, B. Ding, Z.H. Li, G. Audi   +39 more
doaj   +1 more source

Nuclear shock waves in heavy-ion collisions [PDF]

, 2006
It is shown that nuclear matter is compressed during the encounter of heavy ions. If the relative velocity of the nuclei is larger than the velocity of first sound in nuclear matter (compression sound for isospin T=0), nuclear shock waves occur.
Greiner, Walter, Müller, Hans, Scheid, Werner   +2 more
core  

Quark-meson coupling model with the cloudy bag

, 2008
Using the volume coupling version of the cloudy bag model, the quark-meson coupling model is extended to study the role of pion field and the properties of nuclear matter. The extended model includes the effect of gluon exchange as well as the pion-cloud
Capstick, Chin, Dally, DeGrand, Delorme, Donoghue, Donoghue, Entem, Entem, Fritsch, Guichon, Guichon, Inoue, K. Saito, K. Tsushima, Kaiser, Leinweber, Lepage, Li, Lu, Lu, Lutz, Machleidt, Mckeown, Morgan, S. Nagai, Saito, Saito, Saito, Saito, Saito, Saviankou, Smith, Smith, Strauch, T. Miyatsu, Thomas, Thomas, Thomas, Tsushima, Tsushima, Young   +41 more
core   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

The Merger of Two Compact Stars: A Tool for Dense Matter Nuclear Physics

Universe, 2018
We discuss the different signals, in gravitational and electromagnetic waves, emitted during the merger of two compact stars. We will focus in particular on the possible contraints that those signals can provide on the equation of state of dense matter ...
Alessandro Drago, Giuseppe Pagliara, Sergei B. Popov, Silvia Traversi, Grzegorz Wiktorowicz   +4 more
doaj   +1 more source