Results 171 to 180 of about 4,373,503 (314)

Towards a holographic quark-hadron continuity

open access: yes, 2019
We study dense nuclear and quark matter within a single microscopic approach, namely the holographic Sakai-Sugimoto model. Nuclear matter is described via instantons in the bulk, and we show that instanton interactions are crucial for a continuous ...
Fadafan, Kazem Bitaghsir   +2 more
core   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

open access: yesMolecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova   +18 more
wiley   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

open access: yesMolecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma   +9 more
wiley   +1 more source

In-medium effective chiral lagrangians and the pion mass in nuclear matter [PDF]

open access: yes, 1995
We argue that the effective pion mass in nuclear matter obtained from chiral effective lagrangians is unique and does not depend on off-mass-shell extensions of the pion fields as e.g. the PCAC choice. The effective pion mass in isospin symmetric nuclear
Thorsson, Vesteinn, Wirzba, Andreas
core   +1 more source

Half-Skyrmions and the Equation of State for Compact-Star Matter

open access: yes, 2013
The half-skyrmions that appear in dense baryonic matter when skyrmions are put on crystals modify drastically hadron properties in dense medium and affect strongly the nuclear tensor forces, thereby influencing the equation of state (EoS) of dense ...
Dong, Huan   +4 more
core   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte   +10 more
wiley   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

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