Results 71 to 80 of about 5,051,400 (380)

Troponin T3 regulates nuclear localization of the calcium channel Cavβ1a subunit in skeletal muscle [PDF]

open access: yes, 2015
The voltage-gated calcium channel (Cav) β1a subunit (Cavβ1a) plays an important role in excitation-contraction coupling (ECC), a process in the myoplasm that leads to muscle-force generation. Recently, we discovered that the Cavβ1a subunit travels to the
Delbono, Osvaldo   +7 more
core   +2 more sources

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

History and Perspectives of Nuclear Medicine in Thailand [PDF]

open access: yesAsia Oceania Journal of Nuclear Medicine and Biology, 2014
In 1955, the first nuclear medicine division was established in Thailand by Professor Romsai Suwannik in the Department of Radiology, Siriraj Hospil, Mahidol University in Bangkok.
Sombut Boonyaprapa
doaj  

Early Diagnosis of Alzheimer's disease by NIRF Spectroscopy and Nuclear Medicine-v.4.0 [PDF]

open access: yes, 2011
There is an urgent need for the early detection of diseases such as Alzheimer’s (AD) and Cancers in order to enable their successful treatment. Cancer is the second major cause of death after Heart Disease, and AD is the third major cause of death
I Baianu
core   +1 more source

Practical recommendations for radium-223 treatment of metastatic castration-resistant prostate cancer [PDF]

open access: yes, 2017
is the first targeted alpha therapy for patients with castration resistant prostate cancer and symptomatic bone metastases. Radium-223 provides a new treatment option for this setting, but also necessitates a new treatment management approach.
Carrió, Ignasi   +11 more
core   +4 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

Early Diagnosis of Alzheimer's disease by NIRF Spectroscopy and Nuclear Medicine [PDF]

open access: yes, 2011
There is an urgent need for the early detection of diseases such as Alzheimer’s (AD) and Cancers in order to enable their successful treatment. Cancer is the second major cause of death after Heart Disease, and AD is the third major cause of death
I. C. Baianu
core   +1 more source

A genetic algorithm to design Laue lenses with optimal performance for focusing hard X- and gamma-rays

open access: yes, 2014
In order to focus hard X- and gamma-rays it is possible to make use of a Laue lens as a concentrator. With this optical tool it would be possible to improve the detection of radiation for several applications, spanning from the observation of the most ...
Camattari, Riccardo, Guidi, Vincenzo
core   +1 more source

Applications of neutron activation spectroscopy [PDF]

open access: yes, 2013
Since the discovery in 1932, neutrons became a basis of many methods used not only in research, but also in industry and engineering. Among others, the exceptional role in the modern nuclear engineering is played by the neutron activation spectroscopy ...
Silarski, M.
core   +2 more sources

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

open access: yesFEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson   +7 more
wiley   +1 more source

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