Results 91 to 100 of about 1,100,780 (314)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Summary: EANM/SNMMI Release Joint Guideline/Procedure Standard for [F]FDG Hybrid PET Use in Infection and Inflammation in Adults, Version 2.0.

A joint task force of subject-matter experts from the European Association of Nuclear Medicine (EANM) and the Society of Nuclear Medicine and Molecular Imaging (SNMMI) recently released a revised and updated guideline/procedure standard for indications ...
Jamar, F., Israel, O., Pelletier-Galarneau, Matthieu, Gheysens, O., Abikhzer, G., Israel, Ora, Pelletier-Galarneau, M., Gheysens, Olivier, Jamar, François, Treglia, Giorgio, Treglia, G., Abikhzer, Gad   +11 more
core   +1 more source

Nuclear medicine training and practice in Turkey

, 2017
Nuclear medicine applications in Turkey started in the early 1950s, grew as an independent medical discipline and finally were recognized by the Ministry of Health in 1973.
Erbas, Belkis, Ozcan, Zehra, Durak, Hatice, Bozkurt, M. Fani, BOZKURT, MURAT FANİ   +4 more
core   +1 more source

EANM/SNMMI guideline for 18F-FDG use in inflammation and infection. [PDF]

, 2013
The Society of Nuclear Medicine and Molecular Imaging (SNMMI) is an international scientific and professional organization founded in 1954 to promote the science, technology and practical application of nuclear medicine.
Christian PE, Chiti, Arturo, Delbeke, Dominique, Donohoe KJ, Martin Comin J, Jamar, François, Jamar F, Chiti A, Delbeke D, Buscombe, John, Christian, Paul E, Signore, Alberto, Christian, Paul E., Buscombe, John Richard, Buscombe J, Donohoe, Kevin J., Israel, Ora, Donohoe, Kevin J, Martin-Comin, Josep, Israel O   +19 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Parametric Images of Myocardial Viability Using a Single (15)O-H(2)O PET/CT Scan

, 2011
Perfusable tissue index (PTI) is a marker of myocardial viability and requires acquisition of transmission, 15O-CO, and 15O-H2O scans. The aim of this study was to generate parametric PTI images from a 15O-H2O PET/CT scan without an additional 15O-CO ...
Lammertsma, Adriaan A, de Haan, S., Allaart, C.P., Mark Lubberink, Lubberink, J.M., de Haan, Stefan, Lammertsma, A.A., Knaapen, P., Hendrik J. Harms, Paul Knaapen, Knaapen, Paul, Lubberink, Mark,, Allaart, Cornelis P, Harms, H.J., Harms, Hendrik J, Cornelis P. Allaart, Adriaan A. Lammertsma, Stefan de Haan   +17 more
core   +1 more source

Radiolabeled Dendrimers for Nuclear Medicine Applications

Molecules, 2017
Recent advances in nuclear medicine have explored nanoscale carriers for targeted delivery of various radionuclides in specific manners to improve the effect of diagnosis and therapy of diseases.
Lingzhou Zhao, Meilin Zhu, Yujie Li, Yan Xing, Jinhua Zhao   +4 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Forensic Nuclear Medicine [PDF]

Egyptian Journal of Nuclear Medicine, 2018
Saad, I.
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source