Results 71 to 80 of about 84,613 (217)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Cardiac & Lung Nuclear Medicine Exams

Iranian South Medical Journal, 2011
This book has three chapters: Heart, lung and radiation protection. In each chapter, indications of scans, radiopharaceuticals the study performance, patient preparation, report and also possible problems were discussed.
Majid Assadi, Masood Moslehi
doaj  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Acute complications of nuclear medicine: an emergency medicine perspective

EJNMMI Research
Background Nuclear medicine procedures are increasingly integrated into routine clinical practice worldwide, including in low- and middle-income settings.
Mehmet Necmeddin Sutaşır, Banu Arslan, Mohamed Mukhtar Mohamed, Nihat Müjdat Hökenek   +3 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

THERANOSTICS: NUCLEAR MEDICINE IN PROSTATE CANCER

Hematology, Transfusion and Cell Therapy
Summary: Theranostic Nuclear Medicine is based on the idea of combining the same molecule (or drug) with different radioisotopes, both for diagnosis and treatment, a concept that emerged in the early 1940s with thyroid diseases.
Marina Camargo ETCHEBEHERE, Helena da Cunha Lopes DE LIMA, Mariana da Cunha Lopes DE LIMA, Elba Cristina Sá de Camargo ETCHEBEHERE   +3 more
doaj   +3 more sources

Perspectives of nuclear medicine professionals on artificial intelligence and educational implications

Discover Artificial Intelligence
Objective We aimed to evaluate nuclear medicine professionals’ attitudes and perceptions of artificial intelligence (AI) in their field and medicine in general.
Hongyan Yin, Dai Shi, Can Meng
doaj   +1 more source

What are the expectations of patients regarding the communication of nuclear imaging results? Insights from a French national survey of 723 patients

BMJ Open
Objectives There are still some controversies regarding the role of nuclear medicine practitioners in delivering imaging findings to the patients as well as content and magnitude of information to be delivered.
David Taïeb, Julien Mancini, Sandra Gonzalez, Frederic Comte, Fabrice Rezungles, Pierre Le coz, Jean-Marc Israël, Hamza Benjelloun   +7 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source