Results 121 to 130 of about 6,917,354 (302)

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Nuclear medicine imaging of inflammatory diseases

, 2013
Inflammatory diseases are often relapsing and require life-long treatment. New specific targeted therapies are being developed, and several clinical trials are being performed to assess the efficacy and safety of this new approach.
Alberto Signore, Glaudemans, Andor W.J.M.; id_orcid, Andor W.J.M. Glaudemans, Malviya, Gaurav, Glaudemans, Andor W.J.M., Chianelli, Marco, Gaurav Malviya, Signore, Alberto, Marco Chianelli, Glaudemans A. W., Signore A., Malviya G., Chianelli M.   +12 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Status of F-18 FDG uptake in hibernating and normal myocardium in euglycemic hyperinsulinemic condition

, 2017
Annual Meeting of the Society-of-Nuclear-Medicine-and-Molecular-Imaging (SNMMI) -- JUN 10-14, 2017 -- Denver, CO[Abstract Not Available]Soc Nucl Med & Mol ...
Elgazzar, Abdelhamid, Sarikaya, Ismet, Sarikaya, Ali, Alfeeli, Mahmoud   +3 more
core   +1 more source

Development and validation of survival prognostic models for head and neck cancer patients using machine learning and dosiomics and CT radiomics features: a multicentric study

Radiation Oncology
Background This study aimed to investigate the value of clinical, radiomic features extracted from gross tumor volumes (GTVs) delineated on CT images, dose distributions (Dosiomics), and fusion of CT and dose distributions to predict outcomes in head and
Zahra Mansouri, Yazdan Salimi, Mehdi Amini, Ghasem Hajianfar, Mehrdad Oveisi, Isaac Shiri, Habib Zaidi   +6 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Regional impact of time-to-equilibrium on indirect Patlak whole-body parametric imaging: a multi-tissue class analysis at the entire body level

EJNMMI Physics
Purpose Patlak parametric imaging is widely employed for kinetic modeling due to its simplicity and robustness. The time-to-equilibrium (t*), which must be defined to estimate kinetic parameters, is currently set empirically and uniformly across the ...
Abarnaa Sivapathasundaram, Agnieszka Buffon, Jérôme Ghidaglia, Yannick Jentreau, Léa Gomez, Axelle Jamet, Maïwenn Beau, Natacha Da Fonseca, Kevin Harnais, Stéphane Onephandara, Widad Makhlouf, Karim En Nourhi, Emmanuel Durand, Sylvain Faure, Florent L. Besson   +14 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

What is New in Nuclear Medicine Imaging for Dementia. [PDF]

Noro Psikiyatr Ars, 2022
Topçuoğlu ES, Akdemir ÜÖ, Atay LÖ.
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source