Results 121 to 130 of about 903,366 (305)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Scaling in nuclear thermal hydraulics [PDF]

Scaling is a reference “key-word” in engineering and in physics. The relevance of scaling in the water-cooled nuclear reactor technology constitutes the motivation for this chapter, notwithstanding scaling is considered in different parts of this book ...
Nakamura, Hideo, D'auria, Francesco, Reventós Puigjaner, Francesc Josep, Bersano, Andrea, Reyes, José N., Mascari, Fluvio, Freixa Terradas, Jordi   +6 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Editorial: Irradiation technologies for vaccine development

Frontiers in Immunology, 2023
Viskam Wijewardana, Sebastian Ulbert, Giovanni Cattoli   +2 more
doaj   +1 more source

DiffNMR: diffusion models for nuclear magnetic resonance spectra elucidation

Materials Futures
Nuclear magnetic resonance (NMR) spectroscopy is a key method for molecular structure elucidation. However, interpreting NMR spectra to deduce molecular structures remains challenging due to the complexity of spectral data and the vastness of the ...
Qingsong Yang, Binglan Wu, Xuwei Liu, Bo Chen, Wei Li, Gen Long, Xin Chen, Mingjun Xiao   +7 more
doaj   +1 more source

Applications and Prospects of Graph Retrieval-Augmented Generation Technology Based on Large Language Models in the Nuclear Power Field

发电技术
ObjectivesTo address the challenges faced by new types of nuclear power systems in ensuring energy supply, promoting clean energy transition, and achieving “dual carbon” goals, such as structural diversification, load uncertainty, and data complexity ...
XU Haoran, ZHANG Jinyun, MA Xin, LEI Wenqiang, CAO Jieming   +4 more
doaj   +1 more source

Nuclear unclear: an investigation of British nuclear power policy, 1945-2005 [PDF]

This thesis traces the development of policy and the regulatory framework for the commercial nuclear power industry in the United Kingdom between 1945 and 2005. It is argued that throughout the whole period politicians have legitimised their decisions in
Sneddon, Simon
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Radiochemistry and nuclear chemistry / [PDF]

, 2002
Radiochemistry or Nuclear Chemistry is the study of radiation from an atomic or molecular perspective, including elemental transformation and reaction effects, as well as physical, health and medical properties.
Rydberg, Jan., Liljenzin, Jan-Olov., Choppin, Gregory R.   +2 more
core  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source