Results 71 to 80 of about 1,958,095 (294)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

open access: yesFEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard   +12 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

Non-convex weighted ℓp nuclear norm based ADMM framework for image restoration [PDF]

open access: yes, 2020
Inspired by the fact that the matrix formed by nonlocal similar patches in a natural image is of low rank, the nuclear norm minimization (NNM) has been widely used in various image processing studies.
Yuan, Xin   +6 more
core   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

open access: yesFEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas   +6 more
wiley   +1 more source

Multi-Attribute Missing Data Reconstruction Based on Adaptive Weighted Nuclear Norm Minimization in IoT

open access: yesIEEE Access, 2018
In the Internet of Things, data sets gathered from sensor nodes are missing a significant fraction of data, owing to noise, collision, unreliable links, and unexpected damage.
Xiang Yu, Xia Fan, Kan Chen, Sirui Duan
doaj   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

open access: yesFEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph   +7 more
wiley   +1 more source

Low-Rank Tensor Completion for Image and Video Recovery via Capped Nuclear Norm

open access: yesIEEE Access, 2019
Inspired by the robustness and efficiency of the capped nuclear norm, in this paper, we apply it to 3D tensor applications and propose a novel low-rank tensor completion method via tensor singular value decomposition (t-SVD) for image and video recovery.
Xi Chen   +5 more
doaj   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

open access: yesFEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen   +5 more
wiley   +1 more source

A Unified Proximity Algorithm with Adaptive Penalty for Nuclear Norm Minimization [PDF]

open access: yesSymmetry, 2019
The nuclear norm minimization (NNM) problem is to recover a matrix that minimizes the sum of its singular values and satisfies some linear constraints simultaneously. The alternating direction method (ADM) has been used to solve this problem recently.
Wenyu Hu, Weidong Zheng, Gaohang Yu
openaire   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

open access: yesFEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh   +2 more
wiley   +1 more source

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