Results 61 to 70 of about 1,797 (255)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

A new development of non-local image denoising using fixed-point iteration for non-convex ℓp sparse optimization.

open access: yesPLoS ONE, 2018
We proposed a new efficient image denoising scheme, which mainly leads to four important contributions whose approaches are different from existing ones.
Shuting Cai   +5 more
doaj   +1 more source

Joint Nuclear Norm and ℓ1–2-Regularization Sparse Channel Estimation for mmWave Massive MIMO Systems

open access: yesIEEE Access, 2020
Millimeter-wave massive MIMO can effectively improve the signal-to-noise ratio, but the high-dimensional channel matrix significantly increases the complexity of the classic channel estimation algorithm.
Kaiwen Yu, Min Shen, Rui Wang, Yun He
doaj   +1 more source

Drug–target interaction prediction using unifying of graph regularized nuclear norm with bilinear factorization

open access: yesBMC Bioinformatics, 2021
Background Wet-lab experiments for identification of interactions between drugs and target proteins are time-consuming, costly and labor-intensive. The use of computational prediction of drug–target interactions (DTIs), which is one of the significant ...
Ali Ghanbari Sorkhi   +3 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Quaternion Nuclear Norm Minus Frobenius Norm Minimization for color image reconstruction

open access: yesPattern Recognition
This paper was accepted by Pattern Recognition on September 5 ...
Yu Guo 0008   +4 more
openaire   +2 more sources

Image Denoising via Nonlocal Low Rank Approximation With Local Structure Preserving

open access: yesIEEE Access, 2019
The nuclear norm minimization method emerged from a patch-based low-rank model leads to an excellent image denoising performance, where the non-local self-similarity over image patches is exploited.
Zhou Liu, Lei Yu, Hong Sun
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

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