Results 31 to 40 of about 376,302 (266)

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Uncertainty and Sensitivity Analysis of Input Parameters in the CANDLE Module: A Morris–Sobol–LHS–Iman–Conover Framework

Journal of Nuclear Engineering
In this study, an uncertainty quantification (UQ) and sensitivity analysis (SA) workflow was developed for the input parameters of the CANDLE module, which is currently being tested and verified for calculating the downward relocation and solidification ...
Fenghui Yang, Wanhong Wang, Rubing Ma, Xiaoming Yang   +3 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Nuclear power and nuclear-weapons proliferation [PDF]

Physics Today, 1978
For decades, nuclear power has been considered a major component in the energy supply plans of some countries and an important option for the future in others. Like other energy sources, especially oil, nuclear power has become linked to national security and economic health in many countries; the magnitude of fuel reserves and the assurance of supply ...
Moniz, Ernest J., Neff, Thomas L.
openaire   +2 more sources

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Fracture analysis of the planet support used in a nuclear power plant

MATEC Web of Conferences, 2016
In this paper, the fracture analysis of the planet support, which was made of aluminium alloy and used in an electric actuator, was investigated. The laboratory analysis was conducted to find out whether there are defects generated during manufacturing ...
Zu Shuai, Guo Xingang, Xu Guangliang, Chen Liangjia, Che Yinhui, Guan Jianjun   +5 more
doaj   +1 more source

Nuclear Power, Democracy, Development, and Nuclear Warheads: Determinants for Introducing Nuclear Power [PDF]

SSRN Electronic Journal, 2019
This paper analyzes the nature of democratic development in a nation on the process of introducing nuclear power over the period 1960 - 2017 for an unbalanced panel of 171 countries. Given the involved political process of introducing nuclear power and its political importance, as well as the current tendency of about 30 countries to “go nuclear”, this
Sorge, Lars, Neumann, Anne, von Hirschhausen, Christian R., Wealer, Ben   +3 more
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source