Results 71 to 80 of about 1,567,265 (357)

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Research Progress in the Preparation Technology of Radium-223

Journal of Isotopes
223Ra is a low toxicity substance α Radiotherapy nuclide, which can be used to treat castrated resistant prostate cancer (CRPC) with symptoms of bone metastasis and no visceral metastasis, was the first approved alpha therapy radiopharmaceutical on the ...
Junshan GENG, Jianrong WU, Qian XIAO, Bo LI, Yunming CHEN, Jingsong ZHANG, Ning LUO   +6 more
doaj   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity

Molecular Oncology, EarlyView.
Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause, Rixa‐Mareike Köhn, Christian Ickes, Julia Lenger, Jonas Fischer, Sabrina Cappello, Ivan Bogeski   +6 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

A guide to reactive oxygen species in tumour hypoxia: measurement and therapeutic implications

Molecular Oncology, EarlyView.
Hypoxia reshapes tumour redox landscapes by altering compartmental ROS production (mitochondria, NOX, ER, peroxisomes). Accurate interpretation requires oxygen‐contextualised measurement (live biosensors, chemical probes, EPR, LC–MS) and awareness of artefacts (reoxygenation, probe specificity).
Lina Hacker, Elysia Sarsam, Stuart J. Conway, Ester M. Hammond   +3 more
wiley   +1 more source

Preparation of a Platinum-Coated Copper and its Adsorption Performance on Gaseous Iodine

Journal of Isotopes
To develop efficient and easily recoverable iodine adsorbent materials，a platinum coated copper (PCC) material coated with platinum on the surface of copper powder was prepared and used for the adsorption of gaseous iodine.
Bo LI, Shibin LI, Chang LIU, Ning LUO, Fu XUE, Yunming CHEN, Jinsong ZHANG   +6 more
doaj   +1 more source

Fluidelastic instability of a tube array in two-phase cross-flow considering the effect of tube material

Nuclear Engineering and Technology, 2019
Fluidelastic instability of a tube array is a key factor of the security of a nuclear power plant. An unsteady model of the fluidelastic instability of a tube array subjected to two-phase flow was developed to analyze the fluidelastic instability of tube
Huantong Liu, Jiang Lai, Lei Sun, Pengzhou Li, Lixia Gao, Danping Yu   +5 more
doaj   +1 more source

Theoretical Aspects of Science with Radioactive Nuclear Beams [PDF]

, 1997
Physics of radioactive nuclear beams is one of the main frontiers of nuclear science today. Experimentally, thanks to technological developments, we are on the verge of invading the territory of extreme N/Z ratios in an unprecedented way.
Alm T., Batty C. J., Belyaev S. T., Borzov I. N., Cugnon J., Dobaczewski J., Fröbrich P., Gmuca S., Goodman A. L., Goriely S., Haensel P., Hofmann S., IsoSpin, Jacek Dobaczewski, Kadmenski S. G., Kadmenski S. G., Kadmenski S. G., Kamerdzhiev S., Kucharek H., Kvasil J., Lind P., Palumbo F., Patyk Z., Pfeiffer B., Reinhard P.-G., Sagawa H., Sapershten E., Schneider R., Shen Y., Smirnov A. V., Staudt A., Tondeur F., Uchiyama T., W. Gelletly, Witold Nazarewicz, Zverev M. V., Zverev M. V., Zverev M. V.   +37 more
core   +2 more sources