Results 51 to 60 of about 452,569 (335)
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Development and Application of AP1000 Nuclear Power Plant Equipment Reliability Database
南方能源建设, 2022 [Introduction] The important value of equipment reliability data in nuclear power plant PSA, RCM, maintenance rules, reliability assurance program, risk guide management and other fields, puts forward the necessity of developing AP1000 equipment ...
Tianzuo QU, Qishu FANG, Yanlong QIAO
doaj +1 more source
EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
Molecular Oncology, EarlyView.The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
wiley +1 more source
Economics of nuclear energy [PDF]
, 2012 While few people now believe that nuclear power would provide ‘power too cheap to meter’, there is still a common perception that nuclear power is a cheap source of electricity.
Thomas, Stephen
core
Molecular Oncology, EarlyView.Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi +12 more
wiley +1 more source
EnergiesThis study is focused on developing a machine learning (ML) meta-model to predict the progression of a multiple steam generator tube rupture (MSGTR) accident in the APR1400 reactor.
Sonia Spisak, Aya Diab
doaj +1 more source
SEISMIC ISOLATION OF NUCLEAR POWER PLANTS
Nuclear Engineering and Technology, 2014 Seismic isolation is a viable strategy for protecting safety-related nuclear structures from the effects of moderate to severe earthquake shaking. Although seismic isolation has been deployed in nuclear structures in France and South Africa, it has not seen widespread use because of limited new build nuclear construction in the past 30 years and a lack
ANDREW S. WHITTAKER +2 more
openaire +3 more sources
The financial crisis and nuclear power [PDF]
, 2009 An assessment of the impact of the financial crisis on the prospects for new nuclear power plant orders ...
Hall, David, Thomas, Stephen
core
Molecular Oncology, EarlyView.RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha +10 more
wiley +1 more source
Decrypting cancer's spatial code: from single cells to tissue niches
Molecular Oncology, EarlyView.Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik +4 more
wiley +1 more source