Results 51 to 60 of about 471,607 (356)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Study on Elastic-plastic fracture mechanics assessment method of a pipe having multiple circumferential surface cracks for the Rules on Fitness-for-Service of JSME

Nihon Kikai Gakkai ronbunshu, 2019
This paper describes elastic-plastic fracture mechanics assessment methods of a pipe having multiple circumferential cracks. Ductile fracture strength of a multiple cracked pipe was evaluated using J-integral based on a reference stress method.
Hideo MACHIDA, Toshiki OKAMOTO, Shinji YOSHIDA   +2 more
doaj   +1 more source

Underground nuclear power plant siting [PDF]

, 1972
This study is part of a larger evaluation of the problems associated with siting nuclear power plants in the next few decades. This evaluation is being undertaken by the Environmental Quality Laboratory of the California Institute of Technology in ...
Beck, R. L., Kammer, W. A., Langley, N. P., Selzer, L. A., Watson, M. B.   +4 more
core  

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Estimating the economic cost of setting up a nuclear power plant at Rooppur in Bangladesh [PDF]

, 2022
Gour Gobinda Goswami, Umama Rahman, Mehdi Chowdhury   +2 more
openalex   +1 more source

Lessons Learned in Protection of the Public for the Accident at the Fukushima Daiichi Nuclear Power Plant [PDF]

, 2017
What insights can the accident at the Fukushima Daiichi nuclear power plant provide in the reality of decision making on actions to protect the public during a severe reactor and spent fuel pool emergency?
Callen, J., Homma, T.
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Development and Application of AP1000 Nuclear Power Plant Equipment Reliability Database

南方能源建设, 2022
[Introduction] The important value of equipment reliability data in nuclear power plant PSA, RCM, maintenance rules, reliability assurance program, risk guide management and other fields, puts forward the necessity of developing AP1000 equipment ...
Tianzuo QU, Qishu FANG, Yanlong QIAO
doaj   +1 more source

The Paks Nuclear Power Plant: scientific inventions - practical applications [PDF]

, 1999
A fair question may be what lessons and messages a presentation of a nuclear power plant that was conceptualized in the sixties-seventies and commissioned in the eighties tan provide.
Katona, Tamás János
core