Results 61 to 70 of about 77,215 (314)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

AI-Assisted Forecasting of a Mitigated Multiple Steam Generator Tube Rupture Scenario in a Typical Nuclear Power Plant

Energies
This study is focused on developing a machine learning (ML) meta-model to predict the progression of a multiple steam generator tube rupture (MSGTR) accident in the APR1400 reactor.
Sonia Spisak, Aya Diab
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Rotordynamic Analysis of the AM600 Turbine-Generator Shaftline

Energies, 2018
The AM600 represents the conceptual design and layout of a Nuclear Power Plant Turbine Island intended to address challenges associated with emerging markets interested in nuclear power.
Tshimangadzo Mudau, Robert Murray Field
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Dynamic Multiphysics Simulation of the Load-Following Behavior in a Typical Pressurized Water Reactor Power Plant

Energies
Most Nuclear Power Plants (NPPs) are designed for baseload operations, maintaining a steady power output at 100%, except during planned maintenance and refueling.
Ivan Panciak, Aya Diab
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

The Optimal Integration of Virtual Power Plants for the South African National Grid Based on an Energy Mix as per the Integrated Resource Plan 2019: A Review

Energies
The Integrated Resource Plan (IRP) 2019 outlines South Africa’s goal of achieving a diverse and sustainable energy mix. To achieve this, innovative methods must be found to integrate renewable energy sources while preserving grid stability. Virtual Power
Melissa-Jade Williams, Choong-Koo Chang
doaj   +1 more source

Fukushima Nuclear Power Plant Accident and Nuclear Physicists

EPJ Web of Conferences, 2014
I give an overview on the Fukushima Nuclear Power Plant Accident and a report on voluntary activities of Japanese nuclear physicists in this terrible event, including their major outcome.
Otsuka Takaharu
doaj   +1 more source