Results 61 to 70 of about 1,246,840 (403)

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Resilient Design in Nuclear Energy: Critical Lessons from a Cross-Disciplinary Review of the Fukushima Dai-ichi Nuclear Accident [PDF]

arXiv, 2023
Nuclear energy has been gaining momentum recently as one of the solutions to tackle climate change. However, significant environmental and health-risk concerns remain associated with potential accidents. Despite significant preventive efforts, we must acknowledge that accidents may happen and, therefore, develop strategies and technologies for ...
arxiv  

The Fukushima Daiichi Nuclear Power Plant accident and school bullying of affected children and adolescents: the need for continuous radiation education

Journal of Radiation Research, 2018
The health threats of radiation-release incidents are diverse and long term. In addition to direct radiation effects, it is imperative to manage the indirect effects of radiation such as stigma, prejudice and broader mental health impacts.
T. Sawano, Y. Nishikawa, Akihiko Ozaki, C. Leppold, M. Tsubokura   +4 more
semanticscholar   +1 more source

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

Molecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou, Argyro Roumeliotou, Evangelia Pantazaka, Athanasios‐Nasir Shaukat, Athina Christopoulou, Angelos Koutras, Foteinos‐Ioannis Dimitrakopoulos, Vassilis Georgoulias, Anastasia Xagara, Evangelia Chantzara, Fillipos Koinis, Athanasios Kotsakis, Constantinos Stathopoulos, Galatea Kallergi   +13 more
wiley   +1 more source

Caesium-rich micro-particles: A window into the meltdown events at the Fukushima Daiichi Nuclear Power Plant

Scientific Reports, 2017
The nuclear disaster at the Fukushima Daiichi Nuclear Power Plant (FDNPP) in March 2011 caused partial meltdowns of three reactors. During the meltdowns, a type of condensed particle, a caesium-rich micro-particle (CsMP), formed inside the reactors via ...
Genki Furuki, J. Imoto, Asumi Ochiai, Shinya Yamasaki, K. Nanba, T. Ohnuki, B. Grambow, R. Ewing, S. Utsunomiya   +8 more
semanticscholar   +1 more source

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

Molecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran, Clarence Yapp, Gregory J. Baker, Johanna Beyer, Young Hwan Chang, Allison L. Creason, Robert Krueger, Jeremy Muhlich, Nathan Heath Patterson, Kevin Sidak, Damir Sudar, Adam J. Taylor, Luke Ternes, Jakob Troidl, Xie Yubin, Artem Sokolov, Darren R. Tyson   +16 more
wiley   +1 more source

Quantitative Assessment of Gaseous Effluents during Routine Operation: A Comparative Study of Planned Nuclear Power Plants at Lubiatowo-Kopalino and Pątnów Sites in Poland

Science and Technology of Nuclear Installations
On September 2021, Polish government declared that six pressurized water reactors with combined capacity of 6–9 GWe will be built by 2040 to reduce Poland’s reliance on coal. Due to the adopted schedule, construction of the first nuclear power plant will
Edyta Agata Macieja, Juyoul Kim
doaj   +1 more source

Study on Elastic-plastic fracture mechanics assessment method of a pipe having multiple circumferential surface cracks for the Rules on Fitness-for-Service of JSME

Nihon Kikai Gakkai ronbunshu, 2019
This paper describes elastic-plastic fracture mechanics assessment methods of a pipe having multiple circumferential cracks. Ductile fracture strength of a multiple cracked pipe was evaluated using J-integral based on a reference stress method.
Hideo MACHIDA, Toshiki OKAMOTO, Shinji YOSHIDA   +2 more
doaj   +1 more source

Predicting BWR Criticality with Data-Driven Machine Learning Model [PDF]

Transactions of the American Nuclear Society, 2022, 127(1), pp. 1118-1121
One of the challenges in operating nuclear power plants is to decide the amount of fuel needed in a cycle. Large-scale nuclear power plants are designed to operate at base load, meaning that they are expected to always operate at full power. Economically, a nuclear power plant should burn enough fuel to maintain criticality until the end of a cycle ...
arxiv   +1 more source

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source