Results 91 to 100 of about 1,731,332 (381)

Chromosome positioning is largely unaffected in lymphoblastoid cell lines containing emerin or A-type lamin mutations [PDF]

, 2005
Gene-poor human chromosomes are reproducibly found at the nuclear periphery in proliferating cells. There are a number of inner nuclear envelope proteins that may have roles in chromosome location and anchorage, e.g. emerin and A-type lamins.
Bridger, JM, Levy, N, Meaburn, KJ, Toniolo, D   +3 more
core   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Contact sites between inner and outer membranes [PDF]

, 1990
Contact sites between both mitochondrial membranes play a predominant role in the transport of nuclear-coded precursor proteins into mitochondria. The characterization of contact sites was greatly advanced by the reversible accumulation of precursor ...
Attardi, Chen, Dumont, Eilers, Hackenbrock, Hartl, Hartl, Hartl, Hawlitschek, Hurt, Kellems, Nargang, Nicholson, Ostermann, Pfaller, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Pon, Rassow, Rosenberg, Schleyer, Schwaiger, Stuart, Sztul, Söllner, Söllner, Vestweber   +30 more
core   +1 more source

Nucleoplasmic signals promote directed transmembrane protein import simultaneously via multiple channels of nuclear pores

Nature Communications, 2020
The contribution of central and peripheral channels of nuclear pores to transport of transmembrane proteins is unclear. Here the authors show that most inner nuclear membrane proteins use only peripheral channels, but some extend nuclear localization ...
Krishna C. Mudumbi, Rafal Czapiewski, Andrew Ruba, Samuel L. Junod, Yichen Li, Wangxi Luo, Christina Ngo, Valentina Ospina, Eric C. Schirmer, Weidong Yang   +9 more
doaj   +1 more source

The Role of Protein Disorder in Nuclear Transport and in Its Subversion by Viruses

Cells, 2020
The transport of host proteins into and out of the nucleus is key to host function. However, nuclear transport is restricted by nuclear pores that perforate the nuclear envelope.
Jacinta M. Wubben, Sarah C. Atkinson, Natalie A. Borg   +2 more
doaj   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

A monopartite nuclear localization sequence regulates nuclear targeting of the actin binding protein myopodin [PDF]

, 2005
Myopodin is an actin bundling protein that shuttles between nucleus and cytoplasm in response to cell stress or during differentiation. Here, we show that the myopodin sequence (58)KKRRRRARK(66), when tagged to either enhanced green fluorescent protein ...
De Corte, Veerle, De Ganck, Ariane, Geelen, Danny, Gettemans, Jan, Hubert, Thomas, Van Impe, Katrien, Vandekerckhove, Joël   +6 more
core   +1 more source

Active Nuclear Import of Membrane Proteins Revisited

Cells, 2015
It is poorly understood how membrane proteins destined for the inner nuclear membrane pass the crowded environment of the Nuclear Pore Complex (NPC). For the Saccharomyces cerevisiae proteins Src1/Heh1 and Heh2, a transport mechanism was proposed where ...
Justyna K. Laba, Anton Steen, Petra Popken, Alina Chernova, Bert Poolman, Liesbeth M. Veenhoff   +5 more
doaj   +1 more source

Identification of Human Proteins vulnerable to multiple Organisms and their disease associations [PDF]

arXiv, 2016
While most studies emphasize on certain aspects of Pathogen-Host Interactions (PHI), such as the preferential attachment of bacteria or virus to its human receptor homolog, studies have attempted to methodically classify interactions among pathogenic proteins and their host proteins.
arxiv  

Steady-state fluctuations of a genetic feedback loop with fluctuating rate parameters using the unified colored noise approximation [PDF]

arXiv, 2020
A common model of stochastic auto-regulatory gene expression describes promoter switching via cooperative protein binding, effective protein production in the active state and dilution of proteins. Here we consider an extension of this model whereby colored noise with a short correlation time is added to the reaction rate parameters -- we show that ...
arxiv