Results 41 to 50 of about 6,528,274 (245)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

The first unbound states of mirror 9Be and 9B nuclei

EPJ Web of Conferences, 2017
The structures of the first excited states of mirror 9Be and 9B nuclei are studied by using the α + α + N three-body model and the complex scaling method.
Odsuren Myagmarjav, Kikuchi Yuma, Myo Takayuki, Aikawa Masayuki, Katō Kiyoshi   +4 more
doaj   +1 more source

C12+16O molecular resonances at deep sub-barrier energy

Physics Letters B, 2020
The existence of C12+16O molecular resonances at sub-barrier energy has been a significant problem in nuclear astrophysics because they strongly affect the C12+16O fusion reaction rate in type Ia supernovae and heavy stars.
Yasutaka Taniguchi, Masaaki Kimura
doaj   +1 more source

Reinvestigating the Gamow Factor of Reactions on Light Nuclei

The Astrophysical Journal, 2023
We present a modified Gamow factor by reinvestigating the conventional assumptions used in its derivation. The conventional Gamow factor, factorized from the total cross section, effectively describes the penetration probabilities (PPs) in low-energy ...
Eunseok Hwang, Heamin Ko, Kyoungsu Heo, Myung-Ki Cheoun, Dukjae Jang   +4 more
doaj   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

FEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki, Masae Ohtsuka, Takeshi Nakano, Masaru Tanokura, Takuya Miyakawa   +4 more
wiley   +1 more source

The oxygen puzzle in FLASH radiotherapy: A comprehensive review and experimental outlook

Clinical and Translational Radiation Oncology
FLASH radiotherapy is attracting increasing interest because it maintains tumor control while inflicting less damage to normal tissues compared to conventional radiotherapy.
Andrea Scarmelotto, Victor Delprat, Carine Michiels, Stéphane Lucas, Anne-Catherine Heuskin   +4 more
doaj   +1 more source

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Neutron transfer and nuclear breakup in²⁰⁸Pb(¹¹Li,⁹Li) reaction

Eurasian Journal of Physics and Functional Materials, 2021
Neutron transfer and nuclear breakup processes in reaction with weakly bound nucleus 11Li at energies near the Coulomb barrier are investigated in the framework of the time-dependent Schrödinger equation.
A. K. Azhibekov, V. V. Samarin, K. A. Kuterbekov   +2 more
doaj   +1 more source