Results 41 to 50 of about 775,419 (311)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

One nucleon transfer operator and nuclear supersymmetry [PDF]

open access: yes, 2005
The appropriate use of the interacting boson-fermion model one nucleon transfer operator in connection with nuclear supersymmetries is discussed. We emphasize that care must be taken in using the same coupling order, either l-s or s-l, in
J. Jolie   +7 more
core   +1 more source

First nuclear reaction measurement using the CARME array

open access: yes, 2023
The broad outline of nucleosynthesis is well established; however, our understanding of it is not yet complete. In many cases, advances in astronomical observations have placed the burden of further understanding on an improved understanding of key ...
Marsh, Jordan
core   +1 more source

The first unbound states of mirror 9Be and 9B nuclei

open access: yesEPJ Web of Conferences, 2017
The structures of the first excited states of mirror 9Be and 9B nuclei are studied by using the α + α + N three-body model and the complex scaling method.
Odsuren Myagmarjav   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

The oxygen puzzle in FLASH radiotherapy: A comprehensive review and experimental outlook

open access: yesClinical and Translational Radiation Oncology
FLASH radiotherapy is attracting increasing interest because it maintains tumor control while inflicting less damage to normal tissues compared to conventional radiotherapy.
Andrea Scarmelotto   +4 more
doaj   +1 more source

C12+16O molecular resonances at deep sub-barrier energy

open access: yesPhysics Letters B, 2020
The existence of C12+16O molecular resonances at sub-barrier energy has been a significant problem in nuclear astrophysics because they strongly affect the C12+16O fusion reaction rate in type Ia supernovae and heavy stars.
Yasutaka Taniguchi, Masaaki Kimura
doaj   +1 more source

Reinvestigating the Gamow Factor of Reactions on Light Nuclei

open access: yesThe Astrophysical Journal, 2023
We present a modified Gamow factor by reinvestigating the conventional assumptions used in its derivation. The conventional Gamow factor, factorized from the total cross section, effectively describes the penetration probabilities (PPs) in low-energy ...
Eunseok Hwang   +4 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

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