Results 61 to 70 of about 712,904 (293)

Direct and Indirect Measurements of the ¹⁹F(p,α)¹⁶O Reaction at Astrophysical Energies Using the LHASA Detector and the Trojan Horse Method

Universe
Fluorine is one of the most interesting elements in nuclear astrophysics. Its abundance can provide important hints to constrain the stellar models since fluorine production and destruction are strictly connected to the physical conditions inside the ...
Giovanni L. Guardo, Giuseppe G. Rapisarda, Dimiter L. Balabanski, Giuseppe D’Agata, Alessia Di Pietro, Pierpaolo Figuera, Marco La Cognata, Marco La Commara, Livio Lamia, Dario Lattuada, Catalin Matei, Marco Mazzocco, Alessandro A. Oliva, Sara Palmerini, Teodora Petruse, Rosario G. Pizzone, Stefano Romano, Maria Letizia Sergi, Roberta Spartá, Xuedou Su, Aurora Tumino, Nikola Vukman   +21 more
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Optimization Method Applied to Theoretical Calculation of Fission Nuclear Reaction

Yuanzineng kexue jishu, 2022
Nuclear data are fundamental data for nuclear energy, nuclear engineering, nuclear technology applications and nuclear science research, and have always received national attention.
TIAN Yuan;XU Ruirui;ZHANG Yue;TAO Xi;WANG Jimin;JIN Yongli;ZHANG Zhi;SUN Xiaodong;GE Zhigang
doaj  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Progress and Prospect of Basic Research on Nuclear Physics in China Institute of Atomic Energy

Yuanzineng kexue jishu
The recent progress and prospect on the nuclear physics at the China Institute of Atomic Energy (CIAE) was summarized in this paper. Significant advancements have been made in nuclear reaction mechanisms, nuclear structure, nuclear astrophysics, nuclear ...
YANG Lei, LIN Chengjian, LI Congbo, LI Gexing, ZHANG Yingxun, LYU Chong, JIA Huiming, ZHENG Yun, LI Yunju, GAO Zaochun, ZHAO Baozhen, WEN Peiwei, WU Xiaoguang, WANG Youbao, ZHAO Kai, XI Xiaofeng, LIAN Gang, YAN Shengquan, NAN Wei, LIAN Zhanjiang, MA Nanru, ZHAO Qiang, YANG Feng, YAN Yuliang, ZENG Sheng, LI Tianxiao, LIAO Junhui, HE Chuangye, WANG Zhao, SHEN Yangping, LI Zhihong, GUO Bing, LIU Weiping, WANG Naiyan, ZHANG Huanqiao
doaj   +1 more source

Towards many-body based nuclear reaction modelling

EPJ Web of Conferences, 2016
The increasing need for cross sections far from the valley of stability poses a challenge for nuclear reaction models. So far, predictions of cross sections have relied on more or less phenomenological approaches, depending on parameters adjusted to ...
Hilaire Stéphane, Goriely Stéphane
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source