Results 81 to 90 of about 434,092 (313)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Superconductivity and low-energy nuclear reactions
Results in Physics, 2019 It is proposed that the excess-energy released in Low-Energy Nuclear Reactions (aka cold fusion) is initiated in a phase-transition yielding a fraction of superconducting electrons, which then start a deuteron-driven chain of nuclear reactions recently ...
Frederick J. Mayer
doaj +1 more source
Unnuclear physics: Conformal symmetry in nuclear reactions. [PDF]
Proc Natl Acad Sci U S A, 2021 Hammer HW, Son DT.
europepmc +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
NUCLEAR REACTIONS AND NUCLEAR STRUCTURE
Acta Physica Sinica, 1962 This article reviews the methods of studying the nuclear structure by means of the nuclear reaction as a tool for investigation. It is divided into two parts. The first part is mainly concerned with the properties of the individual low-lying levels of nuclei, a brief outline being given to describe the present situation of cumulation of experimental ...
openaire +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Gas jet targets for direct reaction studies
Frontiers in PhysicsThe study of direct reactions is of broad interest in nuclear physics, providing constraint to models of nuclear structure evolution and data to better understand the creation of the elements.
K. A. Chipps
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