Results 91 to 100 of about 28,439 (160)

Phloretic Acid Improves Metabolic Dysfunction-Associated Steatotic Liver Disease in High-Fat Diet-Fed Mice. [PDF]

Molecules
Park S, Kim H, Jung UJ.
europepmc   +1 more source

PVT1 lincRNA signals an androgen‐dependent transcriptional activation program of oncogenes in prostate cancer cells

International Journal of Cancer, Volume 159, Issue 1, Page 144-158, 1 July 2026.
What's New? Unraveling the networks that regulate androgen receptor (AR) function is critical to better understanding prostate cancer development and progression. Of particular interest in this regard is the long non‐coding RNA PVT1, which regulates gene expression in cancer and is upregulated in prostate tumors.
Maria Gabriela Berzoti‐Coelho, Fabio Nunes de Mello, Ana Carolina Tahira, Gabriel Nakanishi Fortes, Agatha Fischer‐Carvalho, Pedro Jardim Poli, Murilo Sena Amaral, Sergio Verjovski‐Almeida   +7 more
wiley   +1 more source

P2X7R deficiency alleviates cardiac senescence by enhancing mitophagy via the HuR/TRIM26/NR4A1 axis. [PDF]

Clin Transl Med
Zhou Y, Zhong X, Mao Z, Chen Y, Xing J, Shen J, Zhang W, Zhang J, Mei J, Yang Z, Wang Z, Ye B, Lin J, Wang Y, Huang Z.   +14 more
europepmc   +1 more source

Vitamin‐Responsive Disorders: From Molecular Basis to Clinical Presentation and Therapy

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT Vitamin‐dependent cofactors are essential for numerous metabolic reactions, and defects affecting their uptake, conversion, utilisation, or regeneration constitute a heterogeneous group of inherited metabolic disorders (IMDs). Although dietary vitamin intake is sufficient to sustain coenzyme synthesis in healthy individuals, it is insufficient
Cécile Acquaviva, Yann Nadjar, Manuel Schiff, Christine Vianey‐Saban, Alain Fouilhoux, Jean‐François Benoist   +5 more
wiley   +1 more source

Dimethyl Fumarate Reverses β-Adrenoceptor-Mediated Myocardial Fibrosis in Mice by Inhibiting Yes-Associated Protein-Regulated Expression of Intermediate-Conductance Ca²⁺-Activated K⁺ Channel in Fibroblasts. [PDF]

J Am Heart Assoc
Wu LH, Bai RY, Chen JY, Pang ZD, Hai XX, Han MZ, Yang YY, Wang Y, Zhang Y, Zhang J, She G, Du XJ, Deng XL.   +12 more
europepmc   +1 more source

Bidirectional Relationship and Shared Mechanisms Between Sarcopenia and Osteoporosis: An Observational Study Integrating Genomic, Proteomic, and Metabolomic Data

Aging Cell, Volume 25, Issue 7, July 2026.
This study investigated the bidirectional relationship and shared mechanisms between sarcopenia and osteoporosis using data from the UK Biobank. Our findings indicated that the two conditions may act as reciprocal risk factors, with multiple potential biomarkers mediating the muscle‐bone relationship and suggested possible shared signals between the ...
Siqi Xu, Simin Wen, Xizeng Zong, Jianwei Zhu, Qiuling Du, Yu Li, Kunyan Wang, Peihua Cao, Changhai Ding, Yan Zhang, Guangfeng Ruan   +10 more
wiley   +1 more source

Pharmacogenes Associated with Suicidal Behavior: Addressing a Potential Therapeutic Window. [PDF]

Actas Esp Psiquiatr
Becerra López JA, Genis Mendoza AD, Nicolini H.   +2 more
europepmc   +1 more source

Defining AV2‐1 as a novel pharmacological probe to target human and rodent TRPV2

British Journal of Pharmacology, Volume 183, Issue 13, Page 3538-3557, July 2026.
Abstract Background and Purpose Transient receptor potential vanilloid 2 (TRPV2) is a non‐selective cation channel implicated in immune cell functions. However, progress in understanding TRPV2 has been limited by a lack of potent and selective pharmacological tools, particularly those targeting the human variant. We aimed to identify and characterise a
Andrea Leipe, Julia A. Rocereta, Ruth A. Pumroy, Andreas Leffler, Michael Schaefer, Vera Moiseenkova‐Bell, Kerstin Hill   +6 more
wiley   +1 more source

MARCH2 prevents doxorubicin-induced cardiomyopathy by stabilizing NR1H2 and promoting clearance of apoptotic cardiomyocytes. [PDF]

Nat Commun
Liu S, Li YE, Zhu T, Zhang L, Yang C, Bi Y, Bao C, Hu R, Ge J, Zhang Y.   +9 more
europepmc   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, Volume 293, Issue 13, Page 3717-3757, July 2026.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source