Results 1 to 10 of about 156 (85)

NR2F1-AS1 Promotes Pancreatic Ductal Adenocarcinoma Progression Through Competing Endogenous RNA Regulatory Network Constructed by Sponging miRNA-146a-5p/miRNA-877-5p

Frontiers in Cell and Developmental Biology, 2021
The role of NR2F1-AS1 in pancreatic ductal adenocarcinoma (PDAC) remains unknown. Therefore, we aimed to investigate the biological mechanism of NR2F1-AS1 in PDAC. The expression of NR2F1-AS1 was measured by using microarray data and real-time PCR.
Dong Luo, Hongwei Zhu, Xiao Yu
exaly   +3 more sources

Long noncoding RNA NR2F1-AS1 stimulates the tumorigenic behavior of non-small cell lung cancer cells by sponging miR-363-3p to increase SOX4

Open Medicine (Poland), 2021
Long noncoding RNA (lncRNA), specifically the upregulation of lncRNA NR2F1 antisense RNA 1 (NR2F1-AS1), has been involved in the progression of non-small cell lung cancer (NSCLC), but the mechanisms that underlie this remain unclear.
Jin Luming, Chen Chaoyang, Huang Lipeng, Sun Qingyu, Bu Liang   +4 more
exaly   +2 more sources

The Parkinson’s-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1

Cell Reports, 2021
Summary: Increasing evidence suggests that neurodevelopmental alterations might contribute to increase the susceptibility to develop neurodegenerative diseases.
Jonas Walter, Silvia Bolognin, Suresh Poovathingal   +2 more
exaly   +3 more sources

Imbalance of Excitatory/Inhibitory Neuron Differentiation in Neurodevelopmental Disorders with an NR2F1 Point Mutation

Cell Reports, 2020
Summary: Recent studies have revealed an essential role for embryonic cortical development in the pathophysiology of neurodevelopmental disorders, including autism spectrum disorder (ASD).
Jiehui Chen, Yingying Chen, Xianfa Yang   +2 more
exaly   +3 more sources

LncRNA NR2F1-AS1 inhibits the malignant properties of cervical cancer cells via targeting miR-642a-3p/NR2F1 axis

Revista de Investigación Clínica, 2022
Background: Cervical cancer (CC), as a serious menace to the health of women, has long been one of the most lethal gynecologic neoplasms throughout the world.
Lingyan Zhang, Yanhua Zhang, Jianbo Zhou, Yongfang Wang, Haihong Wang, Mei Huang, Qiulan Yu, Qi Sun   +7 more
doaj   +1 more source

The EMT-induced lncRNA NR2F1-AS1 positively modulates NR2F1 expression and drives gastric cancer via miR-29a-3p/VAMP7 axis

Cell Death and Disease, 2022
Deregulated lncRNAs play critical roles in tumorigenesis and tumor progression. NR2F1-AS1 is an antisense lncRNA of NR2F1. However, the biological function of NR2F1-AS1 in gastric cancer (GC) remains largely unclear. In this study, we revealed that NR2F1-
Dandan Li, Mengjie Xu, Zidi Wang, Pan Huang, Congcong Huang, Zhen Chen, Gaijuan Tang, Xingji Zhu, Mengyu Cai, Shanshan Qin   +9 more
doaj   +1 more source

Hypoxia-induced long noncoding RNA NR2F1-AS1 maintains pancreatic cancer proliferation, migration, and invasion by activating the NR2F1/AKT/mTOR axis

Cell Death and Disease, 2022
Accumulating evidence has demonstrated the essential role of long noncoding RNAs (lncRNAs) in various types of human cancer, including pancreatic cancer (PC). However, the functions and regulatory mechanisms of nuclear receptor subfamily 2 group F member
Yanqing Liu, Shiyu Chen, Kun Cai, Dijie Zheng, Changhao Zhu, Lin Li, Feiqing Wang, Zhiwei He, Chao Yu, Chengyi Sun   +9 more
doaj   +1 more source

A coregulatory network of NR2F1 and microRNA-140. [PDF]

PLoS ONE, 2013
Both nuclear receptor subfamily 2 group F member 1 (NR2F1) and microRNAs (miRNAs) have been shown to play critical roles in the developing and functional inner ear.
David Y Chiang, David W Cuthbertson, Fernanda R Ruiz, Na Li, Fred A Pereira   +4 more
doaj   +1 more source

The differentiation and integration of the hippocampal dorsoventral axis are controlled by two nuclear receptor genes

eLife, 2023
The hippocampus executes crucial functions from declarative memory to adaptive behaviors associated with cognition and emotion. However, the mechanisms of how morphogenesis and functions along the hippocampal dorsoventral axis are differentiated and ...
Xiong Yang, Rong Wan, Zhiwen Liu, Su Feng, Jiaxin Yang, Naihe Jing, Ke Tang   +6 more
doaj   +1 more source

Pathophysiological Heterogeneity of the BBSOA Neurodevelopmental Syndrome

Cells, 2022
The formation and maturation of the human brain is regulated by highly coordinated developmental events, such as neural cell proliferation, migration and differentiation.
Michele Bertacchi, Chiara Tocco, Christian P. Schaaf, Michèle Studer   +3 more
doaj   +1 more source