Results 11 to 20 of about 3,079 (182)

Unravelling the conundrum of nucleolar NR2F1 localization using antibody-based approaches in vitro and in vivo [PDF]

Communications Biology
As a transcription factor, NR2F1 regulates spatiotemporal gene expression in the nucleus particularly during development. Aberrant NR2F1 causes the rare neurodevelopmental disorder Bosch-Boonstra-Schaaf Optic Atrophy Syndrome.
Michele Bertacchi, Susanne Theiß, Ayat Ahmed, Michael Eibl, Agnès Loubat, Gwendoline Maharaux, Wanchana Phromkrasae, Krittalak Chakrabandhu, Aylin Camgöz, Marco Antonaci, Christian Patrick Schaaf, Michèle Studer, Magdalena Laugsch   +12 more
doaj   +3 more sources

A pathogenic NR2F1 gene variant disrupts transcriptional activity and causes severe neurodevelopmental delay in Bosch-Boonstra-Schaaf syndrome [PDF]

Hereditas
Introduction Nuclear receptor subfamily 2, group F, member 1 (NR2F1) gene variations are associated with Bosch–Boonstra–Schaaf optic atrophy syndrome.
Juan Liu, Jihong Hu, Pingqiu Zhou, Yaqin Duan, Shuigui Yin   +4 more
doaj   +3 more sources

Exosome-delivered NR2F1-AS1 and NR2F1 drive phenotypic transition from dormancy to proliferation in treatment-resistant prostate cancer via stabilizing hormonal receptors [PDF]

Journal of Nanobiotechnology
Cancer cells acquire the ability to reprogram their phenotype in response to targeted therapies, yet the transition from dormancy to proliferation in drug-resistant cancers remains poorly understood.
Wenbin Chen, Yiyou Mao, YiYuan Zhan, Wenfeng Li, Jun Wu, Xiangming Mao, Bin Xu, Fangpeng Shu   +7 more
doaj   +4 more sources

NR2F1 Mutations Cause Optic Atrophy with Intellectual Disability [PDF]

The American Journal of Human Genetics, 2014
Item does not contain fulltextOptic nerve atrophy and hypoplasia can be primary disorders or can result from trans-synaptic degeneration arising from cerebral visual impairment (CVI).
Muzny, Donna M., Gonzaga-Jauregui, C., Zoghbi, Huda Y., Cremers, F.P.M., Lewis, Richard A., Wiszniewski, W., Schaaf, Christian P., Pfundt, R.P., Jhangiani, S., Tsai, Ming-Jer, Gibbs, R.A., Ligt, J. de, de Vries, Bert B.A., Lupski, J.R., Vries, B. de, Bosch, Daniëlle G.M., Jhangiani, Shalini, Blokland, Ellen A.W., Gibbs, Richard A., Lupski, James R., Boonstra, F.N., Bosch, D.G.M., Boonstra, F. Nienke, Spruijt, Liesbeth, Muzny, D.M., Zoghbi, H.Y., Xu, Mafei, Pfundt, Rolph, Yntema, Helger G., Wiszniewski, Wojciech, Blokland, E.A.W., Vissers, Lisenka E.L.M., Lewis, R.A., Tsai, M.J., Tsai, Sophia Y., Cremers, Frans P.M., de Ligt, Joep, Spruijt, L., Schaaf, C.P., Vissers, L.E.L.M., Gonzaga-Jauregui, Claudia, Chen, C.A., Xu, M., Tsai, S.Y., et al., Chen, Chun-An, Yntema, H.G.   +46 more
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NR2F1 stratifies dormant disseminated tumor cells in breast cancer patients [PDF]

Breast Cancer Research, 2018
Background The presence of disseminated tumor cells (DTCs) in bone marrow (BM) is an independent prognostic factor in early breast cancer but does not uniformly predict outcome. Tumor cells can persist in a quiescent state over time, but clinical studies
Elin Borgen, Maria C. Rypdal, Maria Soledad Sosa, Anne Renolen, Ellen Schlichting, Per E. Lønning, Marit Synnestvedt, Julio A. Aguirre-Ghiso, Bjørn Naume   +8 more
doaj   +8 more sources

The topography of corticopontine projections is controlled by postmitotic expression of the area-mapping gene Nr2f1 [PDF]

Development, 2022
Axonal projections from layer V neurons of distinct neocortical areas are topographically organized into discrete clusters within the pontine nuclei during the establishment of voluntary movements.
Leergaard, Trygve B., Bjaalie, Jan G., Tocco, Chiara, Øvsthus, Martin   +3 more
core   +5 more sources

SOX2 and NR2F1 coordinate the gene expression program of the early postnatal visual thalamus [PDF]

Biology Open
ABSTRACT The thalamic dorsolateral geniculate nucleus (dLGN) receives visual input from the retina via the optic nerve, and projects to the cortical visual area, where eye-derived signals are elaborated. The transcription factors SOX2 and NR2F1 are directly involved in the differentiation of dLGN neurons, based on mouse work and ...
Linda Serra, Anna Nordin, Mattias Jonasson, Carolina Marenco, Guido Rovelli, Annika Diebels, Francesca Gullo, Sergio Ottolenghi, Federico Zambelli, Michèle Studer, Giulio Pavesi, Claudio Cantù, Silvia K. Nicolis, Sara Mercurio   +13 more
doaj   +5 more sources

The gene desert mammary carcinoma susceptibility locus Mcs1a regulates Nr2f1 modifying mammary epithelial cell differentiation and proliferation. [PDF]

PLoS Genetics, 2013
Genome-wide association studies have revealed that many low-penetrance breast cancer susceptibility loci are located in non-protein coding genomic regions; however, few have been characterized.
Bart M G Smits, Jill D Haag, Anna I Rissman, Deepak Sharma, Ann Tran, Alexi A Schoenborn, Rachael C Baird, Dan S Peiffer, David Q Leinweber, Matthew J Muelbl, Amanda L Meilahn, Mark R Eichelberg, Ning Leng, Christina Kendziorski, Manorama C John, Patricia A Powers, Caroline M Alexander, Michael N Gould   +17 more
doaj   +2 more sources

Elevated NR2F1 Underlies the Persistence of Invasive Disease After Treatment of BRAF-Mutant Melanoma [PDF]

J Clin Invest
Despite the success of targeted inhibitors in cutaneous melanoma, therapeutic responses are limited by the aged tumor microenvironment and drug-tolerant residual cells.
Teh, Jessica L. F., Aplin, Andrew E., Fane, Mitchell E., Haj, Jelan I., da Silva, Renaira Oliveira, Hacohen, Nir, Aguirre-Ghiso, Julio A., Stefanski, Casey D., Rosenbaum, Sheera, Davies, Michael A., Purwin, Timothy J., Weeraratna, Ashani T., Kadamb, Rama, Chhabra, Yash, Capparelli, Claudia, Erkes, Dan A., Cai, Weijia, Chua, Vivian, Chervoneva, Inna, Tiago, Manoela, Villanueva, Jessie   +20 more
core   +2 more sources

Long non-coding RNA NR2F1-AS1 induces breast cancer lung metastatic dormancy by regulating NR2F1 and ΔNp63 [PDF]

Nature Communications, 2021
Disseminated tumor cells often become dormant before awakening for metastatic growth. Here, the authors report that the lncRNA, NR2F1-AS1, is upregulated in dormant mesenchymal-like breast cancer stem-like cells and promotes dissemination but inhibits ...
Yingjie Liu, Peiyuan Zhang, Qiuyao Wu, Houqin Fang, Yuan Wang, Yansen Xiao, Min Cong, Tingting Wang, Yunfei He, Chengxin Ma, Pu Tian, Yajun Liang, Lun-Xiu Qin, Qingcheng Yang, Qifeng Yang, Lujian Liao, Guohong Hu   +16 more
doaj   +3 more sources