Results 41 to 50 of about 3,079 (182)

Novel NR2F1 variant identified by whole-exome sequencing in a patient with Bosch–Boonstra–Schaaf optic atrophy syndrome

Indian Journal of Ophthalmology, 2022
Bosch–Boonstra–Schaaf optic atrophy syndrome (BBSOAS) is an extremely rare autosomal dominant disorder characterized by intellectual disability, developmental delay, seizures, hypotonia, hearing loss, and optic nerve atrophy.
Ayca Kocaaga, Sevgi Yimenicioglu, Haluk Hüseyin Gürsoy   +2 more
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NR2F1 contributes to cancer cell dormancy, invasion and metastasis of salivary adenoid cystic carcinoma by activating CXCL12/CXCR4 pathway

BMC Cancer, 2019
Background Salivary adenoid cystic carcinoma (SACC) can recur after removal of the primary tumor and treatment, where they can keep no clinical symptoms and dormant state for 10–15 years. NR2F1 has been demonstrated to regulate the tumor cell dormancy in
Xiao-lei Gao, Min Zheng, Hao-fan Wang, Lu-ling Dai, Xiang-hua Yu, Xiao Yang, Xin Pang, Li Li, Mei Zhang, Sha-sha Wang, Jing-biao Wu, Ya-Jie Tang, Xin-hua Liang, Ya-ling Tang   +13 more
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Pathogenic NR2F1 variants cause a developmental ocular phenotype recapitulated in a mutant mouse model [PDF]

, 2021
Pathogenic NR2F1 variants cause a rare autosomal dominant neurodevelopmental disorder referred to as the Bosch-Boonstra-Schaaf Optic Atrophy Syndrome. Although visual loss is a prominent feature seen in affected individuals, the molecular and cellular ...
Defoort, S, Clark, E, Bertacchi, M, Meunier, I, Liu, GT, Vincent-Delorme, C, Jeanjean, L, Pontikos, N, Avery, RA, Rosser, E, Genomics England Research Consortium, Ahn, SJ, Reddy, MA, Wakeling, E, Kruszewski, AM, Jurkute, N, Giordano, N, Bedoukian, EC, Oluonye, N, Studer, M, Lenaers, G, Han, J, Gardham, A, Holder, GE, Davagnanam, I, Amati-Bonneau, P, Martinez-Monseny, A, Gaggioli, C, Kaliakatsos, M, Dominici, C, Webster, AR, Kim, US, Yu-Wai-Man, P, Tocco, C, Bowman, R, Charif, M, Robson, AG, Caleo, M, Acheson, J, Vidal-Santacana, M, Arno, G   +40 more
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RETRACTED: NR2F1-AS1/miR-190a/PHLDB2 Induces the Epithelial–Mesenchymal Transformation Process in Gastric Cancer by Promoting Phosphorylation of AKT3

Frontiers in Cell and Developmental Biology, 2021
The median survival time of patients with advanced gastric cancer (GC) who received radiotherapy and chemotherapy was <1 year. Epithelial–mesenchymal transformation (EMT) gives GC cells the ability to invade, which is an essential biological mechanism
Jinqi Lv, Jinqi Lv, Jinqi Lv, Jinqi Lv, Simeng Zhang, Simeng Zhang, Simeng Zhang, Simeng Zhang, Yang Liu, Yang Liu, Yang Liu, Yang Liu, Ce Li, Ce Li, Ce Li, Ce Li, Tianshu Guo, Tianshu Guo, Tianshu Guo, Tianshu Guo, Shuairan Zhang, Shuairan Zhang, Shuairan Zhang, Shuairan Zhang, Zenan Li, Zenan Li, Zenan Li, Zenan Li, Zihan Jiao, Zihan Jiao, Zihan Jiao, Zihan Jiao, Haina Sun, Haina Sun, Haina Sun, Haina Sun, Ye Zhang, Ling Xu, Ling Xu, Ling Xu, Ling Xu   +40 more
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Клинико-генетические характеристики синдрома Бош–Бунстра–Шаафа, обусловленного вновь выявленными мутациями в гене NR2F1

, 2020
Bosch–Boonstra–Schaaf optic atrophy is autosomal dominant disorder caused by mutations in the NR2F1 gene. Its common features include optic atrophy and / or hypoplasia, developmental delay, intellectual disability, attention deficit disorder, autism ...
O. L. Mironovich, О. А. Щагина, Е. Л. Дадали, A. O. Borovikov, E. L. Dadali, О. Л. Миронович, O. A. Shchagina, А. О. Боровиков   +7 more
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METTL3 inhibits inflammation of retinal pigment epithelium cells by regulating NR2F1 in an m6A-dependent manner

Frontiers in Immunology, 2022
N6-metyladenosine (m6A) RNA methylation has been proven to be involved in diverse biological processes, but its potential roles in the development of lipopolysaccharide (LPS) induced retinal pigment epithelium (RPE) inflammation have not been revealed ...
Jiayu Meng, Jiayu Meng, Jiayu Meng, Xianyang Liu, Xianyang Liu, Xianyang Liu, Shiyun Tang, Shiyun Tang, Shiyun Tang, Yusen Liu, Yusen Liu, Yusen Liu, Chenyang Zhao, Chenyang Zhao, Chenyang Zhao, Qian Zhou, Qian Zhou, Qian Zhou, Na Li, Shengping Hou, Shengping Hou, Shengping Hou   +21 more
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Expression of transcription factor Coup-TF1 (NR2F1) in developing occipital cortex in humans

, 2015
PURPOSES: We aimed to investigate the presence, distribution and abundance of transcription factor (TF) coup-tf1 (also known as NR2F1) in the germinative zones of human telencephalon during the fetal period.
Angelova, Meglena; Medical University of Varna, Tonchev, Anton B.; Medical University of Varna, Pavlov, Stoyan; Medical University of Varna, Goranova, Vanya; Medical University of Varna, Minkov, Radoslav; Medical University of Varna, Michaleva, Vesselina; Medical University of Varna   +5 more
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NR2F1 Regulates TGF-β1-Mediated Epithelial-Mesenchymal Transition Affecting Platinum Sensitivity and Immune Response in Ovarian Cancer

, 2022
The mechanism underlying platinum resistance in ovarian cancer (OC) remains unclear. We used bioinformatic analyses to screen differentially expressed genes responsible for platinum resistance and explore NR2F1′s correlation with prognostic ...
Yuanhong Liu, Yuanliang Yan, Peng, Bi, Yan, Yuanliang, Xu, Zhijie, Cai, Yuan, Liang, Qiuju, Liu, Wei, Liu, Yuanhong, Yuan Cai, Qiuju Liang, Bi Peng, Zhijie Xu, Wei Liu   +13 more
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Polycomb recruitment attenuates retinoic acid–induced transcription of the bivalent NR2F1 gene [PDF]

Nucleic Acids Research, 2013
Polycomb proteins play key roles in mediating epigenetic modifications that occur during cell differentiation. The Polycomb repressive complex 2 (PRC2) mediates the tri-methylation of histone H3 lysine 27 (H3K27me3). In this study, we identify a distinguishing feature of two classes of PRC2 target genes, represented by the Nr2F1 (Coup-TF1) and the ...
Laursen, Kristian B., Mongan, Nigel P., Zhuang, Yong, Ng, Mary M., Benoit, Yannick D., Gudas, Lorraine J.   +5 more
openaire   +3 more sources

Role of lncRNA NR2F1-AS1 and lncRNA H19 Genes in Hepatocellular Carcinoma and Their Effects on Biological Function of Huh-7

Cancer Management and Research, 2021
Wen-Chao Ji,1 Guang-Jian Bao,1 Fang-Wu Yang,2 Lei Sun,1 Rui Han1 1Department of Hepatobiliary Surgery, Zaozhuang Municipal Hospital, Zaozhuang, 277100 Shandong Province, People’s Republic of China; 2General Surgery Department, Zaozhuang Mining ...
Ji WC, Bao GJ, Yang FW, Sun L, Han R
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