Results 91 to 100 of about 1,147,829 (292)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Filtrated K-theory for real rank zero C*-algebras

, 2011
Using Kirchberg KK_X-classification of purely infinite, separable, stable, nuclear C*-algebras with finite primitive ideal space, Bentmann showed that filtrated K-theory classifies purely infinite, separable, stable, nuclear C*-algebras that satisfy that
Arklint, Sara, Restorff, Gunnar, Ruiz, Efren   +2 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Preconditioned flow as a solution to the hierarchical growth problem in the generalized Lefschetz thimble method

Journal of High Energy Physics
The generalized Lefschetz thimble method is a promising approach that attempts to solve the sign problem in Monte Carlo methods by deforming the integration contour using the flow equation.
Jun Nishimura, Katsuta Sakai, Atis Yosprakob   +2 more
doaj   +1 more source

Coulomb screening effect on the nuclear-pasta structure

, 2004
Using the density functional theory (DFT) with the relativistic mean field (RMF) model, we study the non-uniform state of nuclear matter, ``nuclear pasta''. We self-consistently include the Coulomb interaction together with other interactions.
Chiba, Satoshi, Maruyama, Tomoyuki, Maruyama, Toshiki, Tanigawa, Tomonori, Tatsumi, Toshitaka, Voskresensky, Dmitri N.   +5 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Editorial: Complexity Characteristics of Natural Language

Entropy
The contributions collected in this Special Issue testify to the continued vitality and conceptual breadth of research at the intersection of natural language, complexity science, and information theory [...]
Stanisław Drożdż, Jarosław Kwapień, Tomasz Stanisz   +2 more
doaj   +1 more source

Random Matrices and Chaos in Nuclear Physics: Nuclear Reactions

, 2010
The application of random-matrix theory (RMT) to compound-nucleus (CN) reactions is reviewed. An introduction into the basic concepts of nuclear scattering theory is followed by a survey of phenomenological approaches to CN scattering. The implementation
Mitchell, G. E., Richter, A., Weidenmueller, H. A.   +2 more
core   +1 more source

Nuclear forces: Theory and applications [PDF]

Proceedings of Sixth International Conference on Quarks and Nuclear Physics — PoS(QNP2012), 2012
I review the status of nuclear chiral effective field theory and discuss selected applications focusing on current topics such as the structure of three-nucleon force. I also discuss the discretized version of this approach which treats pions and nucleons as point-like particles on an Euclidean space-time lattice.
openaire   +1 more source