Results 91 to 100 of about 152,566 (264)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

The Statistical Theory of Nuclear Reactions

Physical Review, 1953
It is pointed out that the discrepancies between experimental results and the predictions of the statistical theory of nuclear reactions can be traced to peculiarities in the energy distribution of particles emitted in the breakup of the compound nucleus.
openaire   +3 more sources

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

A topological route to engineering robust and bright supersymmetric laser arrays

Communications Physics
In recent years, several proposals that leverage principles from condensed matter and high-energy physics for engineering laser arrays have been put forward.
Soujanya Datta, Mohammadmahdi Alizadeh, Ramy El-Ganainy, Krishanu Roychowdhury   +3 more
doaj   +1 more source

Light front nuclear theory [PDF]

Nuclear Physics A, 2002
For Proceedings of 3rd International Conference on Perspectives in Hadronic Physics, May ...
openaire   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Quantum decoherence in the Caldeira-Leggett model by the real-time path integral on a computer

Journal of High Energy Physics
We propose first-principle calculations of an open system based on the real-time path integral formalism treating the environment as well as the system of our interest together on a computer.
Jun Nishimura, Hiromasa Watanabe
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Brickwall in rotating BTZ: a dip-ramp-plateau story

Journal of High Energy Physics
In this article, building on our recent investigations and motivated by the fuzzball-paradigm, we explore normal modes of a probe massless scalar field in the rotating BTZ-geometry in an asymptotically AdS spacetime and correspondingly obtain the ...
Suman Das, Arnab Kundu
doaj   +1 more source

Punctuation Patterns in Finnegans Wake by James Joyce Are Largely Translation-Invariant

Entropy
The complexity characteristics of texts written in natural languages are significantly related to the rules of punctuation. In particular, the distances between punctuation marks measured by the number of words quite universally follow the family of ...
Krzysztof Bartnicki, Stanisław Drożdż, Jarosław Kwapień, Tomasz Stanisz   +3 more
doaj   +1 more source