Results 101 to 110 of about 8,482,913 (303)

Preconditioned flow as a solution to the hierarchical growth problem in the generalized Lefschetz thimble method

Journal of High Energy Physics
The generalized Lefschetz thimble method is a promising approach that attempts to solve the sign problem in Monte Carlo methods by deforming the integration contour using the flow equation.
Jun Nishimura, Katsuta Sakai, Atis Yosprakob   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Editorial: Complexity Characteristics of Natural Language

Entropy
The contributions collected in this Special Issue testify to the continued vitality and conceptual breadth of research at the intersection of natural language, complexity science, and information theory [...]
Stanisław Drożdż, Jarosław Kwapień, Tomasz Stanisz   +2 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Parallel theoretical study of the two components of the prompt fission neutrons: Dynamically released at scission and evaporated from fully accelerated fragments

EPJ Web of Conferences, 2017
Prompt fission neutrons (PFN) angular and energy distributions for the reaction 235U(nth,f) are calculated as a function of the mass asymmetry of the fission fragments using two extreme assumptions: 1) PFN are released during the neck rupture due to the ...
Carjan Nicolae, Rizea Margarit, Talou Patrick   +2 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

D2-D8 system with massive strings and the Lifshitz spacetimes

Journal of High Energy Physics, 2017
The Romans’ type IIA supergravity allows fundamental strings to have explicit mass term at the tree level. We show that there exists a (F1,D2,D8) brane configuration which gives rise to Lif 4 (2)  × R 1 × S 5 vacua supported by the massive strings.
Harvendra Singh
doaj   +1 more source

Nuclear mass table in deformed relativistic Hartree–Bogoliubov theory in continuum, I: Even–even nuclei

Atomic Data and Nuclear Data Tables, 2022
Kai-Yuan Zhang, M. Cheoun, Yong-Beom Choi, P. Chong, Jian-Min Dong, Zihao Dong, Xia-Xia Du, L. Geng, E. Ha, Xiao-Tao He, C. Heo, Meng-Chit Ho, E. In, Seonghyun Kim, Youngman Kim, Chang-Hwan Lee, Jenny Lee, He-Xuan Li, Zhi-Pan Li, T. Luo, J. Meng, Myeong-Hwan Mun, Z. Niu, C. Pan, P. Papakonstantinou, X. Shang, Cai-Wan Shen, G. Shen, Wei Sun, Xiang-Xiang Sun, C.-K. Tam, Thaivayongnou, Chen Wang, Xingzhi Wang, Sau-Hei Wong, Jia-Wei Wu, Xin-Hui Wu, Xue-Wei Xia, Yijun Yan, R. Yeung, To-Chung Yiu, Shuang-Quan Zhang, Wei Zhang, Xiaoyan Zhang, Qiang Zhao, Shanqi Zhou   +45 more
semanticscholar   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source