Results 121 to 130 of about 8,482,913 (303)
Punctuation Patterns in Finnegans Wake by James Joyce Are Largely Translation-Invariant
EntropyThe complexity characteristics of texts written in natural languages are significantly related to the rules of punctuation. In particular, the distances between punctuation marks measured by the number of words quite universally follow the family of ...
Krzysztof Bartnicki +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Baryon-number — flavor separation in the topological expansion of QCD
Journal of High Energy PhysicsGauge invariance of QCD dictates the presence of string junctions in the wave functions of baryons. In high-energy inclusive processes, these baryon junctions have been predicted to induce the separation of the flows of baryon number and flavor.
David Frenklakh +3 more
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Monte Carlo studies of quantum cosmology by the generalized Lefschetz thimble method
Journal of High Energy PhysicsQuantum cosmology aims at elucidating the beginning of our Universe. Back in early 80’s, Vilenkin and Hartle-Hawking put forward the “tunneling from nothing” and “no boundary” proposals.
Chien-Yu Chou, Jun Nishimura
doaj +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
The Statistical Theory of Nuclear Reactions
Physical Review, 1953 It is pointed out that the discrepancies between experimental results and the predictions of the statistical theory of nuclear reactions can be traced to peculiarities in the energy distribution of particles emitted in the breakup of the compound nucleus.
openaire +3 more sources
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source