Results 91 to 100 of about 4,128,907 (296)
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome
FEBS Letters, EarlyView.In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini +3 more
wiley +1 more source
SensorsAccurate and detailed tissue characterization is a central goal in medical diagnostics, often requiring the combination of multiple imaging modalities.
Björn van Marwick +7 more
doaj +1 more source
Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease
FEBS Letters, EarlyView.Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim +4 more
wiley +1 more source
Nukleonika, 2015 The problem of hydrogen behavior in containment buildings of nuclear reactors belongs to thermal-hydraulic area. Taking into account the size of systems under consideration and, first of all, safety issues, such type of analyses cannot be done by means ...
Bury Tomasz
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Improved Design and Economic Estimation of Cold-End Systems for Inland Nuclear Power Plants
EnergiesReserve sites for coastal nuclear power plants are gradually being depleted, prompting a shift towards the development of inland nuclear power stations.
Wenjie Zhang +3 more
doaj +1 more source
International Journal of Science and Engineering, 2015 Safety is a major concern in the design, operation and development of a nuclear reactor. One aspect of nuclear reactor safety factor is thermal-hydraulics aspect. In a PWR-type nuclear power plant has been used lighter fluid coolant is water or H2O.
Anwar Ilmar Ramadhan +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Study on Peak Shaving Characteristics of Nuclear Power Unit Based on Molten Salt Heat Storage
发电技术ObjectivesNuclear power units have great potential for peak-shaving. However, the peak-valley fluctuations in terminal load and the characteristics of nuclear reactors to maintain stable output seriously affect the safe and efficient operation of nuclear
LIU Songyang +5 more
doaj +1 more source