Results 101 to 110 of about 4,128,907 (296)
TRIGA-2000 Research Reactor Thermal-hydraulic Analysis using RELAP/SCDAPSIM/MOD3.4
International Journal of Technology, 2017 Any events presumed to risk the safety of a nuclear reactor should be analyzed. In a research reactor, the applicability of best estimate thermal-hydraulic codes has been assessed for safety analysis purposes.
Anhar Riza Antariksawan +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Phonon-mediated Nuclear Excitation Transfer
, 2018 Excitation transfer has long been of interest in biophysics, where electronic excitation is transferred from one location to another mediated by photon exchange.
Hagelstein, Peter L
core
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Sheep Cloned by Nuclear Transfer from a Cultured Cell Line
, 1996 SHEEP CLONED BY NUCLEAR TRANSFER FROM A CULTURED CELL LINE Sheep Cloned by Nuclear Transfer from a Cultured Cell Line (380) (-
Campbell, K.H.S. J. McWhir W.A. Ritchie I. Wilmut
core +2 more sources
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both +7 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Convective Heat Transfer in PWR, BWR, CANDU, SMR, and MSR Nuclear Reactors—A Review
EnergiesNuclear reactors are very complex units in which many physical processes occur simultaneously. Efficient heat removal from the reactor core is the most important of these processes.
Daria Sikorska +5 more
doaj +1 more source