Results 151 to 160 of about 33,338 (202)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

The Existential Risks of Nuclear Weapons: A Role for Ethics and Emotions. [PDF]

Philos Technol
Roeser S.
europepmc   +1 more source

People's Responses to Nuclear Weapons: Mapping Post-Cold War Research. [PDF]

Perspect Psychol Sci
Kause A, Fischer H, Mian Z, Fiske ST.
europepmc   +1 more source

Antimicrobial resistance emergence during war: looking for answers beyond antibiotics. [PDF]

Trauma Surg Acute Care Open
Kilgarriff S, Rock C.
europepmc   +1 more source

Cigarette smoke induces FASN-dependent fatty acid metabolic rewiring to drive bladder cancer progression. [PDF]

Cancer Lett
Amara CS, Piyarathna DWB, Kamal AHM, Chan YS, Kami Reddy KR, Ambati CSR, Hassan MK, Shriwas P, Gandhi T, Jain A, Gangnus T, Popli P, Borkar R, Kang SW, Summers SL, Putluri V, Grimm SL, Venkatesh S, Song N, Seeley EH, Hedlich-Dwyer J, Chen SH, Mahajan NP, Jain AK, Dobrolecki LE, Wells GA, Villanueva H, Li J, Liu X, Bollag RJ, Malovannaya A, Jung SY, Lee HS, Asangani IA, Terris MK, Creighton CJ, Ballester LY, Karanam B, Liu S, Lee M, Raju RR, Siddiqui MM, Eberlin LS, Kommagani R, Sreekumar A, Gao J, Young NL, Hodges HC, Coarfa C, Gassman NR, Lerner SP, Lotan Y, Putluri N.   +52 more
europepmc   +1 more source

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Nuclear War

BMJ, 1961
O. Blacklay, A. Holmes-Smith, C. Borg, T. McSweeney, J. Carson, A. W. Moule, H. D. Freeth, M. Parkes, A. Griffiths, E. S. Pope, H. Hassall, H. M. Walker, J. D. Heppleston   +12 more
  +17 more sources

The Threat of Nuclear War

Annals of Internal Medicine, 1982
Excerpt To the editor: We read with dismay the editorial, "The Road Away from Nuclear War," in the September issue (1).
ALEXANDER LEAF, THOMAS A. HALSTED
openaire   +4 more sources

Physicians on Nuclear War

JAMA: The Journal of the American Medical Association, 1985
To the Editor.— The Aug 3,1984, issue ofThe Journalcontained a number of excellent articles relating to medical aspects of nuclear war. Open discussion of this topic is valuable and should be encouraged. However, such dialogue has been unnecessarily constricted by the widespread acceptance of some debatable assumptions, including the following: We ...
openaire   +2 more sources