Results 31 to 40 of about 2,025 (264)
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Nucleate Boiling in Microchannels
Journal of Heat Transfer, 2005 Dong Liu, Poh-Seng Lee and Suresh V. Garimella Purdue University, West Lafayette, Indiana 47907-2088 An understanding of bubble motion and evolution during nucleate boiling is necessary for the analysis of convective heat transfer rates in microchannels.
Liu, D., Lee, P.S., Garimella, S V
openaire +2 more sources
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Ain Shams Engineering Journal, 2014 Experimental investigations on the influences of different contaminants to deionized water have been conducted under the sub-cooled flow boiling heat transfer inside the vertical annulus.
Mohammad Mohsen Sarafraz +1 more
doaj +1 more source
Heat Transfer of Water Flow Boiling in Nanostructured Open Microchannels
Energies, 2023 In recent years, the open microchannel has drawn increasing interest, but severe local dryout limited the heat transfer capability of flow boiling. It was anticipated that nanostructures with exceptional capillary wicking abilities would overcome this ...
Liaofei Yin +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation
FEBS Open Bio, EarlyView.MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima +8 more
wiley +1 more source
Experimental determination of the induction period for the onset of intensive boiling of a subcooled water flow under conditions of unsteady heat release [PDF]
E3S Web of Conferences, 2019 This paper studies prediction of the boiling crisis onset under conditions of the rapid temperature growth of the heat releasing surface washed by a water flow subcooled to the saturation temperature. We obtained experimental data on time delay for rapid
Safarov A., Levin A.
doaj +1 more source
Energies, 2022 Evaporators used in organic Rankine cycles (ORC) are designed using existing flow boiling correlations that are mainly based on HVAC&R data. However, the ORC evaporators employed in the industry typically have larger diameters and operational conditions ...
Alihan Kaya +2 more
doaj +1 more source